Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Anfal Alwan Al-Temimi
  • Aum-El-Bashar Al-Mossawi
  • Sawsan A. Al-Hilifi
  • Sameh A. Korma
  • Tuba Esatbeyoglu
  • João Miguel Rocha
  • Vipul Agarwal

Externe Organisationen

  • University of Basrah
  • Zagazig University
  • South China University of Technology
  • Universidade Católica Portuguesa (UCP)
  • University of New South Wales (UNSW)
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Aufsatznummer465
FachzeitschriftMetabolites
Jahrgang13
Ausgabenummer4
PublikationsstatusVeröffentlicht - 24 März 2023

Abstract

Glutathione is a naturally occurring compound that plays a crucial role in the cellular response to oxidative stress through its ability to quench free radicals, thus mitigating the risk of potential damage, including cell death. While glutathione is endogenously present in different plants and animal cells, their concentration varies considerably. The alteration in glutathione homeostasis can be used as a potential marker for human diseases. In the case of the depletion of endogenous glutathione, exogenous sources can be used to replenish the pool. To this end, both natural and synthetic glutathione can be used. However, the health benefit of glutathione from natural sources derived from fruits and vegetables is still debated. There is increasingly growing evidence of the potential health benefits of glutathione in different diseases; however, the determination and in situ quantification of endogenously produced glutathione remains a major challenge. For this reason, it has been difficult to understand the bioprocessing of exogenously delivered glutathione in vivo. The development of an in situ technique will also aid in the routine monitoring of glutathione as a biomarker for different oxidative stress-mediated diseases. Furthermore, an understanding of the in vivo bioprocessing of exogenously delivered glutathione will also aid the food industry both towards improving the longevity and profile of food products and the development of glutathione delivery products for long-term societal health benefits. In this review, we surveyed the natural plant-derived sources of glutathione, the identification and quantification of extracted glutathione from these sources, and the role of glutathione in the food industry and its effect on human health.

ASJC Scopus Sachgebiete

Ziele für nachhaltige Entwicklung

Zitieren

Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review. / Al-Temimi, Anfal Alwan; Al-Mossawi, Aum-El-Bashar; Al-Hilifi, Sawsan A. et al.
in: Metabolites, Jahrgang 13, Nr. 4, 465, 24.03.2023.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Al-Temimi, AA, Al-Mossawi, A-E-B, Al-Hilifi, SA, Korma, SA, Esatbeyoglu, T, Rocha, JM & Agarwal, V 2023, 'Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review', Metabolites, Jg. 13, Nr. 4, 465. https://doi.org/10.3390/metabo13040465
Al-Temimi, A. A., Al-Mossawi, A.-E.-B., Al-Hilifi, S. A., Korma, S. A., Esatbeyoglu, T., Rocha, J. M., & Agarwal, V. (2023). Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review. Metabolites, 13(4), Artikel 465. https://doi.org/10.3390/metabo13040465
Al-Temimi AA, Al-Mossawi AEB, Al-Hilifi SA, Korma SA, Esatbeyoglu T, Rocha JM et al. Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review. Metabolites. 2023 Mär 24;13(4):465. doi: 10.3390/metabo13040465
Al-Temimi, Anfal Alwan ; Al-Mossawi, Aum-El-Bashar ; Al-Hilifi, Sawsan A. et al. / Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods : A Review. in: Metabolites. 2023 ; Jahrgang 13, Nr. 4.
Download
@article{6d89c39b732e440fa3e51b569bde1d5b,
title = "Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review",
abstract = "Glutathione is a naturally occurring compound that plays a crucial role in the cellular response to oxidative stress through its ability to quench free radicals, thus mitigating the risk of potential damage, including cell death. While glutathione is endogenously present in different plants and animal cells, their concentration varies considerably. The alteration in glutathione homeostasis can be used as a potential marker for human diseases. In the case of the depletion of endogenous glutathione, exogenous sources can be used to replenish the pool. To this end, both natural and synthetic glutathione can be used. However, the health benefit of glutathione from natural sources derived from fruits and vegetables is still debated. There is increasingly growing evidence of the potential health benefits of glutathione in different diseases; however, the determination and in situ quantification of endogenously produced glutathione remains a major challenge. For this reason, it has been difficult to understand the bioprocessing of exogenously delivered glutathione in vivo. The development of an in situ technique will also aid in the routine monitoring of glutathione as a biomarker for different oxidative stress-mediated diseases. Furthermore, an understanding of the in vivo bioprocessing of exogenously delivered glutathione will also aid the food industry both towards improving the longevity and profile of food products and the development of glutathione delivery products for long-term societal health benefits. In this review, we surveyed the natural plant-derived sources of glutathione, the identification and quantification of extracted glutathione from these sources, and the role of glutathione in the food industry and its effect on human health.",
keywords = "bioactive peptides, glutathione, natural peptide, oxidative stress",
author = "Al-Temimi, {Anfal Alwan} and Aum-El-Bashar Al-Mossawi and Al-Hilifi, {Sawsan A.} and Korma, {Sameh A.} and Tuba Esatbeyoglu and Rocha, {Jo{\~a}o Miguel} and Vipul Agarwal",
note = "Funding Information: The authors are grateful to the COST Action 18101 SOURDOMICS—Sourdough biotechnology network towards novel, healthier and sustainable food and bioprocesses ( https://sourdomics.com/ ; https://www.cost.eu/actions/CA18101/ , accessed on 29 January 2023), where the author T.E. is members of the working groups 4, 6, 7 and 8, and the author J.M.F.R. is the Chair and Grant Holder Scientific Representative and is supported by COST (European Cooperation in Science and Technology) ( https://www.cost.eu/ , accessed on 29 January 2023). COST is a funding agency for research and innovation networks. V.A. acknowledges the National Health and Medical Research Council (NHMRC), Australia, for an Early Career Fellowship (GNT1139060) and UNSW Safety Net Fellowship.",
year = "2023",
month = mar,
day = "24",
doi = "10.3390/metabo13040465",
language = "English",
volume = "13",
number = "4",

}

Download

TY - JOUR

T1 - Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods

T2 - A Review

AU - Al-Temimi, Anfal Alwan

AU - Al-Mossawi, Aum-El-Bashar

AU - Al-Hilifi, Sawsan A.

AU - Korma, Sameh A.

AU - Esatbeyoglu, Tuba

AU - Rocha, João Miguel

AU - Agarwal, Vipul

N1 - Funding Information: The authors are grateful to the COST Action 18101 SOURDOMICS—Sourdough biotechnology network towards novel, healthier and sustainable food and bioprocesses ( https://sourdomics.com/ ; https://www.cost.eu/actions/CA18101/ , accessed on 29 January 2023), where the author T.E. is members of the working groups 4, 6, 7 and 8, and the author J.M.F.R. is the Chair and Grant Holder Scientific Representative and is supported by COST (European Cooperation in Science and Technology) ( https://www.cost.eu/ , accessed on 29 January 2023). COST is a funding agency for research and innovation networks. V.A. acknowledges the National Health and Medical Research Council (NHMRC), Australia, for an Early Career Fellowship (GNT1139060) and UNSW Safety Net Fellowship.

PY - 2023/3/24

Y1 - 2023/3/24

N2 - Glutathione is a naturally occurring compound that plays a crucial role in the cellular response to oxidative stress through its ability to quench free radicals, thus mitigating the risk of potential damage, including cell death. While glutathione is endogenously present in different plants and animal cells, their concentration varies considerably. The alteration in glutathione homeostasis can be used as a potential marker for human diseases. In the case of the depletion of endogenous glutathione, exogenous sources can be used to replenish the pool. To this end, both natural and synthetic glutathione can be used. However, the health benefit of glutathione from natural sources derived from fruits and vegetables is still debated. There is increasingly growing evidence of the potential health benefits of glutathione in different diseases; however, the determination and in situ quantification of endogenously produced glutathione remains a major challenge. For this reason, it has been difficult to understand the bioprocessing of exogenously delivered glutathione in vivo. The development of an in situ technique will also aid in the routine monitoring of glutathione as a biomarker for different oxidative stress-mediated diseases. Furthermore, an understanding of the in vivo bioprocessing of exogenously delivered glutathione will also aid the food industry both towards improving the longevity and profile of food products and the development of glutathione delivery products for long-term societal health benefits. In this review, we surveyed the natural plant-derived sources of glutathione, the identification and quantification of extracted glutathione from these sources, and the role of glutathione in the food industry and its effect on human health.

AB - Glutathione is a naturally occurring compound that plays a crucial role in the cellular response to oxidative stress through its ability to quench free radicals, thus mitigating the risk of potential damage, including cell death. While glutathione is endogenously present in different plants and animal cells, their concentration varies considerably. The alteration in glutathione homeostasis can be used as a potential marker for human diseases. In the case of the depletion of endogenous glutathione, exogenous sources can be used to replenish the pool. To this end, both natural and synthetic glutathione can be used. However, the health benefit of glutathione from natural sources derived from fruits and vegetables is still debated. There is increasingly growing evidence of the potential health benefits of glutathione in different diseases; however, the determination and in situ quantification of endogenously produced glutathione remains a major challenge. For this reason, it has been difficult to understand the bioprocessing of exogenously delivered glutathione in vivo. The development of an in situ technique will also aid in the routine monitoring of glutathione as a biomarker for different oxidative stress-mediated diseases. Furthermore, an understanding of the in vivo bioprocessing of exogenously delivered glutathione will also aid the food industry both towards improving the longevity and profile of food products and the development of glutathione delivery products for long-term societal health benefits. In this review, we surveyed the natural plant-derived sources of glutathione, the identification and quantification of extracted glutathione from these sources, and the role of glutathione in the food industry and its effect on human health.

KW - bioactive peptides

KW - glutathione

KW - natural peptide

KW - oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=85153736899&partnerID=8YFLogxK

U2 - 10.3390/metabo13040465

DO - 10.3390/metabo13040465

M3 - Article

VL - 13

JO - Metabolites

JF - Metabolites

IS - 4

M1 - 465

ER -