Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Catherine Victoria
  • Göran Schulz
  • Mara Klöhn
  • Saskia Weber
  • Cora M. Holicki
  • Yannick Brüggemann
  • Miriam Becker
  • Gisa Gerold
  • Martin Eiden
  • Martin H. Groschup
  • Eike Steinmann
  • Andreas Kirschning

Research Organisations

External Research Organisations

  • Ruhr-Universität Bochum
  • University of Veterinary Medicine of Hannover, Foundation
  • Umea University
  • Friedrich Loeffler Institute (FLI)
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Details

Original languageEnglish
Pages (from-to)289-321
Number of pages33
JournalJournal of medicinal chemistry
Volume67
Issue number1
Early online date21 Dec 2023
Publication statusPublished - 11 Jan 2024

Abstract

The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4′, 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol.

ASJC Scopus subject areas

Sustainable Development Goals

Cite this

Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. / Victoria, Catherine; Schulz, Göran; Klöhn, Mara et al.
In: Journal of medicinal chemistry, Vol. 67, No. 1, 11.01.2024, p. 289-321.

Research output: Contribution to journalArticleResearchpeer review

Victoria, C, Schulz, G, Klöhn, M, Weber, S, Holicki, CM, Brüggemann, Y, Becker, M, Gerold, G, Eiden, M, Groschup, MH, Steinmann, E & Kirschning, A 2024, 'Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses', Journal of medicinal chemistry, vol. 67, no. 1, pp. 289-321. https://doi.org/10.1021/acs.jmedchem.3c01357
Victoria, C., Schulz, G., Klöhn, M., Weber, S., Holicki, C. M., Brüggemann, Y., Becker, M., Gerold, G., Eiden, M., Groschup, M. H., Steinmann, E., & Kirschning, A. (2024). Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. Journal of medicinal chemistry, 67(1), 289-321. https://doi.org/10.1021/acs.jmedchem.3c01357
Victoria C, Schulz G, Klöhn M, Weber S, Holicki CM, Brüggemann Y et al. Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. Journal of medicinal chemistry. 2024 Jan 11;67(1):289-321. Epub 2023 Dec 21. doi: 10.1021/acs.jmedchem.3c01357
Victoria, Catherine ; Schulz, Göran ; Klöhn, Mara et al. / Halogenated Rocaglate Derivatives : Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. In: Journal of medicinal chemistry. 2024 ; Vol. 67, No. 1. pp. 289-321.
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AU - Victoria, Catherine

AU - Schulz, Göran

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AU - Weber, Saskia

AU - Holicki, Cora M.

AU - Brüggemann, Yannick

AU - Becker, Miriam

AU - Gerold, Gisa

AU - Eiden, Martin

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AU - Steinmann, Eike

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