Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Catherine Victoria
  • Göran Schulz
  • Mara Klöhn
  • Saskia Weber
  • Cora M. Holicki
  • Yannick Brüggemann
  • Miriam Becker
  • Gisa Gerold
  • Martin Eiden
  • Martin H. Groschup
  • Eike Steinmann
  • Andreas Kirschning

Organisationseinheiten

Externe Organisationen

  • Ruhr-Universität Bochum
  • Stiftung Tierärztliche Hochschule Hannover
  • Universität Umeå
  • Friedrich-Loeffler-Institut (FLI)
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Seiten (von - bis)289-321
Seitenumfang33
FachzeitschriftJournal of medicinal chemistry
Jahrgang67
Ausgabenummer1
Frühes Online-Datum21 Dez. 2023
PublikationsstatusVeröffentlicht - 11 Jan. 2024

Abstract

The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4′, 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol.

ASJC Scopus Sachgebiete

Ziele für nachhaltige Entwicklung

Zitieren

Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. / Victoria, Catherine; Schulz, Göran; Klöhn, Mara et al.
in: Journal of medicinal chemistry, Jahrgang 67, Nr. 1, 11.01.2024, S. 289-321.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Victoria, C, Schulz, G, Klöhn, M, Weber, S, Holicki, CM, Brüggemann, Y, Becker, M, Gerold, G, Eiden, M, Groschup, MH, Steinmann, E & Kirschning, A 2024, 'Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses', Journal of medicinal chemistry, Jg. 67, Nr. 1, S. 289-321. https://doi.org/10.1021/acs.jmedchem.3c01357
Victoria, C., Schulz, G., Klöhn, M., Weber, S., Holicki, C. M., Brüggemann, Y., Becker, M., Gerold, G., Eiden, M., Groschup, M. H., Steinmann, E., & Kirschning, A. (2024). Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. Journal of medicinal chemistry, 67(1), 289-321. https://doi.org/10.1021/acs.jmedchem.3c01357
Victoria C, Schulz G, Klöhn M, Weber S, Holicki CM, Brüggemann Y et al. Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. Journal of medicinal chemistry. 2024 Jan 11;67(1):289-321. Epub 2023 Dez 21. doi: 10.1021/acs.jmedchem.3c01357
Victoria, Catherine ; Schulz, Göran ; Klöhn, Mara et al. / Halogenated Rocaglate Derivatives : Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. in: Journal of medicinal chemistry. 2024 ; Jahrgang 67, Nr. 1. S. 289-321.
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AU - Weber, Saskia

AU - Holicki, Cora M.

AU - Brüggemann, Yannick

AU - Becker, Miriam

AU - Gerold, Gisa

AU - Eiden, Martin

AU - Groschup, Martin H.

AU - Steinmann, Eike

AU - Kirschning, Andreas

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