Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Catherine Victoria
  • Göran Schulz
  • Mara Klöhn
  • Saskia Weber
  • Cora M. Holicki
  • Yannick Brüggemann
  • Miriam Becker
  • Gisa Gerold
  • Martin Eiden
  • Martin H. Groschup
  • Eike Steinmann
  • Andreas Kirschning

Organisationseinheiten

Externe Organisationen

  • Ruhr-Universität Bochum
  • Stiftung Tierärztliche Hochschule Hannover
  • Universität Umeå
  • Friedrich-Loeffler-Institut (FLI)
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Seiten (von - bis)289-321
Seitenumfang33
FachzeitschriftJournal of medicinal chemistry
Jahrgang67
Ausgabenummer1
Frühes Online-Datum21 Dez. 2023
PublikationsstatusVeröffentlicht - 11 Jan. 2024

Abstract

The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4′, 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol.

ASJC Scopus Sachgebiete

Ziele für nachhaltige Entwicklung

Zitieren

Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. / Victoria, Catherine; Schulz, Göran; Klöhn, Mara et al.
in: Journal of medicinal chemistry, Jahrgang 67, Nr. 1, 11.01.2024, S. 289-321.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Victoria, C, Schulz, G, Klöhn, M, Weber, S, Holicki, CM, Brüggemann, Y, Becker, M, Gerold, G, Eiden, M, Groschup, MH, Steinmann, E & Kirschning, A 2024, 'Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses', Journal of medicinal chemistry, Jg. 67, Nr. 1, S. 289-321. https://doi.org/10.1021/acs.jmedchem.3c01357
Victoria, C., Schulz, G., Klöhn, M., Weber, S., Holicki, C. M., Brüggemann, Y., Becker, M., Gerold, G., Eiden, M., Groschup, M. H., Steinmann, E., & Kirschning, A. (2024). Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. Journal of medicinal chemistry, 67(1), 289-321. Vorabveröffentlichung online. https://doi.org/10.1021/acs.jmedchem.3c01357
Victoria C, Schulz G, Klöhn M, Weber S, Holicki CM, Brüggemann Y et al. Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. Journal of medicinal chemistry. 2024 Jan 11;67(1):289-321. Epub 2023 Dez 21. doi: 10.1021/acs.jmedchem.3c01357
Victoria, Catherine ; Schulz, Göran ; Klöhn, Mara et al. / Halogenated Rocaglate Derivatives : Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. in: Journal of medicinal chemistry. 2024 ; Jahrgang 67, Nr. 1. S. 289-321.
Download
@article{c5c1e2864de74b058497e57620b57e5b,
title = "Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses",
abstract = "The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4′, 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol.",
author = "Catherine Victoria and G{\"o}ran Schulz and Mara Kl{\"o}hn and Saskia Weber and Holicki, {Cora M.} and Yannick Br{\"u}ggemann and Miriam Becker and Gisa Gerold and Martin Eiden and Groschup, {Martin H.} and Eike Steinmann and Andreas Kirschning",
note = "Funding Information: E.S. was supported by the German Federal Ministry of Health (ZMVI1-2518FSB705) and a grant of the German Centre for Infection Diseases (DZIF). E.S., M.H.G. and A.K. were supported by the German Ministry of Education and Research (BMBF, project SILVIR: 16GW0202). G.G. received funding from the Lower Saxony Ministry of Science and Culture (15-76251-1-2/23 (511/2023)). ",
year = "2024",
month = jan,
day = "11",
doi = "10.1021/acs.jmedchem.3c01357",
language = "English",
volume = "67",
pages = "289--321",
journal = "Journal of medicinal chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "1",

}

Download

TY - JOUR

T1 - Halogenated Rocaglate Derivatives

T2 - Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses

AU - Victoria, Catherine

AU - Schulz, Göran

AU - Klöhn, Mara

AU - Weber, Saskia

AU - Holicki, Cora M.

AU - Brüggemann, Yannick

AU - Becker, Miriam

AU - Gerold, Gisa

AU - Eiden, Martin

AU - Groschup, Martin H.

AU - Steinmann, Eike

AU - Kirschning, Andreas

N1 - Funding Information: E.S. was supported by the German Federal Ministry of Health (ZMVI1-2518FSB705) and a grant of the German Centre for Infection Diseases (DZIF). E.S., M.H.G. and A.K. were supported by the German Ministry of Education and Research (BMBF, project SILVIR: 16GW0202). G.G. received funding from the Lower Saxony Ministry of Science and Culture (15-76251-1-2/23 (511/2023)).

PY - 2024/1/11

Y1 - 2024/1/11

N2 - The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4′, 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol.

AB - The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4′, 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol.

UR - http://www.scopus.com/inward/record.url?scp=85181007683&partnerID=8YFLogxK

U2 - 10.1021/acs.jmedchem.3c01357

DO - 10.1021/acs.jmedchem.3c01357

M3 - Article

C2 - 38127656

AN - SCOPUS:85181007683

VL - 67

SP - 289

EP - 321

JO - Journal of medicinal chemistry

JF - Journal of medicinal chemistry

SN - 0022-2623

IS - 1

ER -

Von denselben Autoren