Dextrans, Pullulan and Lentinan, New Scaffold Materials for Use as Hydrogels in Tissue Engineering

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  • Hannover Medical School (MHH)
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Original languageEnglish
Article numbere202303843
Number of pages12
JournalChemistry - a European journal
Volume30
Issue number22
Early online date13 Jan 2024
Publication statusPublished - 16 Apr 2024

Abstract

The development of hydrogels based on dextrans, pullulan and lentinan to be used in biomedical applications including tissue engineering is reported. Despite the fact that selected polysaccharides such as hyaluronic acid are well established, little is known, how these polysaccharides can be chemically modified to create hydrogels under controlled conditions. In this study we present a small library of chemically modified polysaccharides which are used for a divergent approach to achieve biomedical relevant hydrogels. In this case the crosslinking is based on thio ether formation between thiol modified donor and vinylsulfone or maleimide modified acceptor components. Successful synthesis of the linker systems and coupling at the polysaccharides, hydrogel formation takes place under physiological conditions. We extended the study by coupling small molecules like adhesion factors for increasing cell compatibility as well as a dye for further studies. The different hydrogels were studied to their rheological properties, water uptake, their permeability, biodegrability and their cytotoxicity.

Keywords

    click chemistry, dextran, hydrogels, lentinan, pullulan

ASJC Scopus subject areas

Cite this

Dextrans, Pullulan and Lentinan, New Scaffold Materials for Use as Hydrogels in Tissue Engineering. / Lienig, Pascal; Banerjee, Samhita; Kenneweg, Franziska et al.
In: Chemistry - a European journal, Vol. 30, No. 22, e202303843, 16.04.2024.

Research output: Contribution to journalArticleResearchpeer review

Lienig P, Banerjee S, Kenneweg F, Thum T, Kirschning A, Dräger G. Dextrans, Pullulan and Lentinan, New Scaffold Materials for Use as Hydrogels in Tissue Engineering. Chemistry - a European journal. 2024 Apr 16;30(22):e202303843. Epub 2024 Jan 13. doi: 10.1002/chem.202303843
Lienig, Pascal ; Banerjee, Samhita ; Kenneweg, Franziska et al. / Dextrans, Pullulan and Lentinan, New Scaffold Materials for Use as Hydrogels in Tissue Engineering. In: Chemistry - a European journal. 2024 ; Vol. 30, No. 22.
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