Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Mohamed A. Farag
  • Eman M. Kabbash
  • Ahmed Mediani
  • Stefanie Döll
  • Tuba Esatbeyoglu
  • Sherif M. Afifi

External Research Organisations

  • Cairo University
  • Universiti Kebangsaan Malaysia
  • Friedrich Schiller University Jena
  • University of Sadat City
View graph of relations

Details

Original languageEnglish
Article number2935
JournalMolecules
Volume27
Issue number9
Publication statusPublished - 4 May 2022

Abstract

The present study aimed to assess metabolites heterogeneity among four major Cin-namomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cas-sia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocy-anidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum versus procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS analysis en-compassing different classes, viz. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species.

Keywords

    chemometrics, Cinnamomum, erythritol, metabolomics, proanthocyanidin

ASJC Scopus subject areas

Sustainable Development Goals

Cite this

Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools. / Farag, Mohamed A.; Kabbash, Eman M.; Mediani, Ahmed et al.
In: Molecules, Vol. 27, No. 9, 2935, 04.05.2022.

Research output: Contribution to journalArticleResearchpeer review

Farag MA, Kabbash EM, Mediani A, Döll S, Esatbeyoglu T, Afifi SM. Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools. Molecules. 2022 May 4;27(9):2935. doi: 10.3390/molecules27092935
Farag, Mohamed A. ; Kabbash, Eman M. ; Mediani, Ahmed et al. / Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools. In: Molecules. 2022 ; Vol. 27, No. 9.
Download
@article{ea0fda99a2dd41268f0c11b9e144d91e,
title = "Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools",
abstract = "The present study aimed to assess metabolites heterogeneity among four major Cin-namomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cas-sia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocy-anidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum versus procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS analysis en-compassing different classes, viz. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species.",
keywords = "chemometrics, Cinnamomum, erythritol, metabolomics, proanthocyanidin",
author = "Farag, {Mohamed A.} and Kabbash, {Eman M.} and Ahmed Mediani and Stefanie D{\"o}ll and Tuba Esatbeyoglu and Afifi, {Sherif M.}",
note = "Funding Information: Funding: The publication of this article was funded by the Open Access Fund of Leibniz Universit{\"a}t Hannover.",
year = "2022",
month = may,
day = "4",
doi = "10.3390/molecules27092935",
language = "English",
volume = "27",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "9",

}

Download

TY - JOUR

T1 - Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools

AU - Farag, Mohamed A.

AU - Kabbash, Eman M.

AU - Mediani, Ahmed

AU - Döll, Stefanie

AU - Esatbeyoglu, Tuba

AU - Afifi, Sherif M.

N1 - Funding Information: Funding: The publication of this article was funded by the Open Access Fund of Leibniz Universität Hannover.

PY - 2022/5/4

Y1 - 2022/5/4

N2 - The present study aimed to assess metabolites heterogeneity among four major Cin-namomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cas-sia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocy-anidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum versus procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS analysis en-compassing different classes, viz. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species.

AB - The present study aimed to assess metabolites heterogeneity among four major Cin-namomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cas-sia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocy-anidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum versus procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS analysis en-compassing different classes, viz. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species.

KW - chemometrics

KW - Cinnamomum

KW - erythritol

KW - metabolomics

KW - proanthocyanidin

UR - http://www.scopus.com/inward/record.url?scp=85130056694&partnerID=8YFLogxK

U2 - 10.3390/molecules27092935

DO - 10.3390/molecules27092935

M3 - Article

VL - 27

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 9

M1 - 2935

ER -

By the same author(s)