Details
| Originalsprache | Englisch |
|---|---|
| Titel des Sammelwerks | Modeling of Microscale Transport in Biological Processes |
| Herausgeber (Verlag) | Elsevier Inc. |
| Seiten | 77-112 |
| Seitenumfang | 36 |
| ISBN (elektronisch) | 9780128046197 |
| ISBN (Print) | 9780128045954 |
| Publikationsstatus | Veröffentlicht - 6 Jan. 2017 |
Abstract
Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
ASJC Scopus Sachgebiete
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
Modeling of Microscale Transport in Biological Processes. Elsevier Inc., 2017. S. 77-112.
Publikation: Beitrag in Buch/Bericht/Sammelwerk/Konferenzband › Beitrag in Buch/Sammelwerk › Forschung › Peer-Review
}
TY - CHAP
T1 - Coupling Microscale Transport and Tissue Mechanics
T2 - Modeling Strategies for Arterial Multiphysics
AU - Marino, M.
AU - Pontrelli, G.
AU - Vairo, G.
AU - Wriggers, P.
PY - 2017/1/6
Y1 - 2017/1/6
N2 - Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
AB - Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
KW - Arterial multiphysics
KW - Arterial tissues
KW - Biomechanics
KW - Microscale transport process
KW - Multiscale constitutive model
KW - Tissue remodeling
KW - Vascular pathologies
UR - http://www.scopus.com/inward/record.url?scp=85026805470&partnerID=8YFLogxK
U2 - 10.1016/b978-0-12-804595-4.00004-3
DO - 10.1016/b978-0-12-804595-4.00004-3
M3 - Contribution to book/anthology
AN - SCOPUS:85026805470
SN - 9780128045954
SP - 77
EP - 112
BT - Modeling of Microscale Transport in Biological Processes
PB - Elsevier Inc.
ER -