Details
| Original language | English |
|---|---|
| Title of host publication | Modeling of Microscale Transport in Biological Processes |
| Publisher | Elsevier Inc. |
| Pages | 77-112 |
| Number of pages | 36 |
| ISBN (Electronic) | 9780128046197 |
| ISBN (Print) | 9780128045954 |
| Publication status | Published - 6 Jan 2017 |
Abstract
Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
Keywords
- Arterial multiphysics, Arterial tissues, Biomechanics, Microscale transport process, Multiscale constitutive model, Tissue remodeling, Vascular pathologies
ASJC Scopus subject areas
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Modeling of Microscale Transport in Biological Processes. Elsevier Inc., 2017. p. 77-112.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Coupling Microscale Transport and Tissue Mechanics
T2 - Modeling Strategies for Arterial Multiphysics
AU - Marino, M.
AU - Pontrelli, G.
AU - Vairo, G.
AU - Wriggers, P.
PY - 2017/1/6
Y1 - 2017/1/6
N2 - Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
AB - Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
KW - Arterial multiphysics
KW - Arterial tissues
KW - Biomechanics
KW - Microscale transport process
KW - Multiscale constitutive model
KW - Tissue remodeling
KW - Vascular pathologies
UR - http://www.scopus.com/inward/record.url?scp=85026805470&partnerID=8YFLogxK
U2 - 10.1016/b978-0-12-804595-4.00004-3
DO - 10.1016/b978-0-12-804595-4.00004-3
M3 - Contribution to book/anthology
AN - SCOPUS:85026805470
SN - 9780128045954
SP - 77
EP - 112
BT - Modeling of Microscale Transport in Biological Processes
PB - Elsevier Inc.
ER -