Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

Organisationseinheiten

Externe Organisationen

  • Università degli studi di Roma Tor Vergata
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Aufsatznummer112058
Seitenumfang13
FachzeitschriftJournal of biomechanics
Jahrgang166
Frühes Online-Datum24 März 2024
PublikationsstatusVeröffentlicht - März 2024

Abstract

This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.

ASJC Scopus Sachgebiete

Zitieren

Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model. / Gierig, Meike; Gaziano, Pierfrancesco; Wriggers, Peter et al.
in: Journal of biomechanics, Jahrgang 166, 112058, 03.2024.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Gierig M, Gaziano P, Wriggers P, Marino M. Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model. Journal of biomechanics. 2024 Mär;166:112058. Epub 2024 Mär 24. doi: 10.1016/j.jbiomech.2024.112058
Download
@article{f800303903f2478bab497fb21c8cc612,
title = "Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model",
abstract = "This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.",
keywords = "Balloon angioplasty, Chemo-mechano-biological model, In silico medicine, Tissue inflammatory response, Vessel remodeling",
author = "Meike Gierig and Pierfrancesco Gaziano and Peter Wriggers and Michele Marino",
note = "Funding Information: MM and PG gratefully acknowledge funding from Regione Lazio (POR FESR LAZIO 2014; Progetti di Gruppi di Ricerca 2020; project: BIOPMEAT, n. A0375-2020-36756) and support from the Italian National Group for Mathematical Physics GNFM-INdAM. PW gratefully acknowledges the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - SFB/TRR-298-SIIRI - Project-ID 426335750.",
year = "2024",
month = mar,
doi = "10.1016/j.jbiomech.2024.112058",
language = "English",
volume = "166",
journal = "Journal of biomechanics",
issn = "0021-9290",
publisher = "Elsevier Ltd.",

}

Download

TY - JOUR

T1 - Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model

AU - Gierig, Meike

AU - Gaziano, Pierfrancesco

AU - Wriggers, Peter

AU - Marino, Michele

N1 - Funding Information: MM and PG gratefully acknowledge funding from Regione Lazio (POR FESR LAZIO 2014; Progetti di Gruppi di Ricerca 2020; project: BIOPMEAT, n. A0375-2020-36756) and support from the Italian National Group for Mathematical Physics GNFM-INdAM. PW gratefully acknowledges the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - SFB/TRR-298-SIIRI - Project-ID 426335750.

PY - 2024/3

Y1 - 2024/3

N2 - This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.

AB - This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.

KW - Balloon angioplasty

KW - Chemo-mechano-biological model

KW - In silico medicine

KW - Tissue inflammatory response

KW - Vessel remodeling

UR - http://www.scopus.com/inward/record.url?scp=85188678647&partnerID=8YFLogxK

U2 - 10.1016/j.jbiomech.2024.112058

DO - 10.1016/j.jbiomech.2024.112058

M3 - Article

AN - SCOPUS:85188678647

VL - 166

JO - Journal of biomechanics

JF - Journal of biomechanics

SN - 0021-9290

M1 - 112058

ER -

Von denselben Autoren