Details
| Original language | English |
|---|---|
| Pages (from-to) | 1487-1492 |
| Number of pages | 6 |
| Journal | Macromolecular Rapid Communications |
| Volume | 33 |
| Issue number | 17 |
| Early online date | 23 Jul 2012 |
| Publication status | Published - 14 Sept 2012 |
| Externally published | Yes |
Abstract
Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.
Keywords
- hemocompatibility, poly(ethylene glycol), polyglycerol, polyimides, surface chemistry
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Materials Science(all)
- Polymers and Plastics
- Materials Science(all)
- Materials Chemistry
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In: Macromolecular Rapid Communications, Vol. 33, No. 17, 14.09.2012, p. 1487-1492.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Surface functionalization of poly(ether imide) membranes with linear, methylated oligoglycerols for reducing thrombogenicity
AU - Lange, Maik
AU - Braune, Steffen
AU - Luetzow, Karola
AU - Richau, Klaus
AU - Scharnagl, Nico
AU - Weinhart, Marie
AU - Neffe, Axel T.
AU - Jung, Friedrich
AU - Haag, Rainer
AU - Lendlein, Andreas
PY - 2012/9/14
Y1 - 2012/9/14
N2 - Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.
AB - Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.
KW - hemocompatibility
KW - poly(ethylene glycol)
KW - polyglycerol
KW - polyimides
KW - surface chemistry
UR - http://www.scopus.com/inward/record.url?scp=84865968485&partnerID=8YFLogxK
U2 - 10.1002/marc.201200426
DO - 10.1002/marc.201200426
M3 - Article
C2 - 22821898
AN - SCOPUS:84865968485
VL - 33
SP - 1487
EP - 1492
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
SN - 1022-1336
IS - 17
ER -