Details
| Original language | English |
|---|---|
| Title of host publication | Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2025 |
| Editors | Tianhong Dai, Tianhong Dai, Jurgen Popp, Mei X. Wu |
| Publisher | SPIE |
| ISBN (electronic) | 9781510683440 |
| Publication status | Published - 19 Mar 2025 |
| Event | SPIE Photonics West BiOS 2025 - San Francisco, United States Duration: 25 Jan 2025 → 31 Jan 2025 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 13298 |
| ISSN (Print) | 1605-7422 |
Abstract
Advances in medical care and an aging population have resulted in an increased routine use of temporary implants, such as catheters or venous shunts. While these devices can greatly improve the quality of life of the patients, they also pose a constant risk of infection. This is especially concerning for vulnerable groups such as cancer and elderly patients. Additionally, each infection that is treated with antibiotics increases the risk of resistance development. Hospitals in particular need to avoid nosocomial infections to prevent spreading of resistant strains and ensure the safety of their patients. There is hence a high demand for innovative solutions to prevent infections in such vulnerable settings. In this context, antimicrobial photodynamic inactivation can serve as an effective means of in situ disinfection for otherwise hard to treat components. In our study, we focus on its possible application on temporary polymer implants such as catheters or shunts. In situ disinfection of such implants requires a non-toxic method and remote application. This can potentially be realized using appropriate waveguides and stable photodynamic agents. The work presented here lays the foundation for such self-disinfecting implants.
Keywords
- antimicrobial materials, antimicrobial photodynamic inactivation, disinfection, implant, photosensitizer, reactive oxygen species, silicone
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Materials Science(all)
- Biomaterials
- Medicine(all)
- Radiology Nuclear Medicine and imaging
Sustainable Development Goals
Cite this
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Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2025. ed. / Tianhong Dai; Tianhong Dai; Jurgen Popp; Mei X. Wu. SPIE, 2025. 1329806 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13298).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Antimicrobial photodynamic inactivation as a means to improve the safety of temporary polymer implants
AU - Rahtz, Alina
AU - Berger, Romina
AU - Schweigerdt, Alexander
AU - Weinhart, Marie
AU - Ripken, Tammo
AU - Johannsmeier, Sonja
N1 - Publisher Copyright: © 2025 SPIE.
PY - 2025/3/19
Y1 - 2025/3/19
N2 - Advances in medical care and an aging population have resulted in an increased routine use of temporary implants, such as catheters or venous shunts. While these devices can greatly improve the quality of life of the patients, they also pose a constant risk of infection. This is especially concerning for vulnerable groups such as cancer and elderly patients. Additionally, each infection that is treated with antibiotics increases the risk of resistance development. Hospitals in particular need to avoid nosocomial infections to prevent spreading of resistant strains and ensure the safety of their patients. There is hence a high demand for innovative solutions to prevent infections in such vulnerable settings. In this context, antimicrobial photodynamic inactivation can serve as an effective means of in situ disinfection for otherwise hard to treat components. In our study, we focus on its possible application on temporary polymer implants such as catheters or shunts. In situ disinfection of such implants requires a non-toxic method and remote application. This can potentially be realized using appropriate waveguides and stable photodynamic agents. The work presented here lays the foundation for such self-disinfecting implants.
AB - Advances in medical care and an aging population have resulted in an increased routine use of temporary implants, such as catheters or venous shunts. While these devices can greatly improve the quality of life of the patients, they also pose a constant risk of infection. This is especially concerning for vulnerable groups such as cancer and elderly patients. Additionally, each infection that is treated with antibiotics increases the risk of resistance development. Hospitals in particular need to avoid nosocomial infections to prevent spreading of resistant strains and ensure the safety of their patients. There is hence a high demand for innovative solutions to prevent infections in such vulnerable settings. In this context, antimicrobial photodynamic inactivation can serve as an effective means of in situ disinfection for otherwise hard to treat components. In our study, we focus on its possible application on temporary polymer implants such as catheters or shunts. In situ disinfection of such implants requires a non-toxic method and remote application. This can potentially be realized using appropriate waveguides and stable photodynamic agents. The work presented here lays the foundation for such self-disinfecting implants.
KW - antimicrobial materials
KW - antimicrobial photodynamic inactivation
KW - disinfection
KW - implant
KW - photosensitizer
KW - reactive oxygen species
KW - silicone
UR - http://www.scopus.com/inward/record.url?scp=105004324107&partnerID=8YFLogxK
U2 - 10.1117/12.3041085
DO - 10.1117/12.3041085
M3 - Conference contribution
AN - SCOPUS:105004324107
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2025
A2 - Dai, Tianhong
A2 - Dai, Tianhong
A2 - Popp, Jurgen
A2 - Wu, Mei X.
PB - SPIE
T2 - SPIE Photonics West BiOS 2025
Y2 - 25 January 2025 through 31 January 2025
ER -