Details
| Original language | English |
|---|---|
| Article number | 651 |
| Journal | Polymers |
| Volume | 15 |
| Issue number | 3 |
| Publication status | Published - 27 Jan 2023 |
Abstract
Different parts of bones possess different properties, such as the capacity for remodeling cell content, porosity, and protein composition. For various traumatic or surgical tissue defects, the application of tissue-engineered constructs seems to be a promising strategy. Despite significant research efforts, such constructs are still rarely available in the clinic. One of the reasons is the lack of resorbable materials, whose properties can be adjusted according to the intended tissue or tissue contacts. Here, we present our first results on the development of a toolbox, by which the scaffolds with easily tunable mechanical and biological properties could be prepared. Biodegradable poly(lactic acid) and nanocrystalline cellulose methacrylated particles were obtained, characterized, and used for preparation of three-dimensional scaffolds via cryogelation and 3D printing approaches. The composition of particles-based ink for 3D printing was optimized in order to allow formation of stable materials. Both the modified-particle cytotoxicity and the matrix-supported cell adhesion were evaluated and visualized in order to confirm the perspectives of materials application.
Keywords
- 3D printing, methacrylation, nanocrystalline cellulose, particles, poly(lactic acid), scaffolds, tissue engineering
ASJC Scopus subject areas
- Chemistry(all)
- Materials Science(all)
- Polymers and Plastics
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In: Polymers, Vol. 15, No. 3 , 651, 27.01.2023.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering
AU - Leonovich, Mariia
AU - Korzhikov-Vlakh, Viktor
AU - Lavrentieva, Antonina
AU - Pepelanova, Iliyana
AU - Korzhikova-Vlakh, Evgenia
AU - Tennikova, Tatiana
N1 - Funding Information: This research was funded by Megagrant of the Ministry of Science and Higher Education of the Russian Federation (#075-15-2021-637).
PY - 2023/1/27
Y1 - 2023/1/27
N2 - Different parts of bones possess different properties, such as the capacity for remodeling cell content, porosity, and protein composition. For various traumatic or surgical tissue defects, the application of tissue-engineered constructs seems to be a promising strategy. Despite significant research efforts, such constructs are still rarely available in the clinic. One of the reasons is the lack of resorbable materials, whose properties can be adjusted according to the intended tissue or tissue contacts. Here, we present our first results on the development of a toolbox, by which the scaffolds with easily tunable mechanical and biological properties could be prepared. Biodegradable poly(lactic acid) and nanocrystalline cellulose methacrylated particles were obtained, characterized, and used for preparation of three-dimensional scaffolds via cryogelation and 3D printing approaches. The composition of particles-based ink for 3D printing was optimized in order to allow formation of stable materials. Both the modified-particle cytotoxicity and the matrix-supported cell adhesion were evaluated and visualized in order to confirm the perspectives of materials application.
AB - Different parts of bones possess different properties, such as the capacity for remodeling cell content, porosity, and protein composition. For various traumatic or surgical tissue defects, the application of tissue-engineered constructs seems to be a promising strategy. Despite significant research efforts, such constructs are still rarely available in the clinic. One of the reasons is the lack of resorbable materials, whose properties can be adjusted according to the intended tissue or tissue contacts. Here, we present our first results on the development of a toolbox, by which the scaffolds with easily tunable mechanical and biological properties could be prepared. Biodegradable poly(lactic acid) and nanocrystalline cellulose methacrylated particles were obtained, characterized, and used for preparation of three-dimensional scaffolds via cryogelation and 3D printing approaches. The composition of particles-based ink for 3D printing was optimized in order to allow formation of stable materials. Both the modified-particle cytotoxicity and the matrix-supported cell adhesion were evaluated and visualized in order to confirm the perspectives of materials application.
KW - 3D printing
KW - methacrylation
KW - nanocrystalline cellulose
KW - particles
KW - poly(lactic acid)
KW - scaffolds
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85147953379&partnerID=8YFLogxK
U2 - 10.3390/polym15030651
DO - 10.3390/polym15030651
M3 - Article
AN - SCOPUS:85147953379
VL - 15
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 3
M1 - 651
ER -