Details
| Original language | English |
|---|---|
| Pages (from-to) | 533-546 |
| Number of pages | 14 |
| Journal | Chemical papers |
| Volume | 78 |
| Issue number | 1 |
| Early online date | 7 Oct 2023 |
| Publication status | Published - Jan 2024 |
Abstract
Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in recent years due to their attractive properties, especially in biomedical applications as delivery vehicle for therapeutic and diagnostic purposes. Here, we present a facile new synthetic strategy to prepare ultra-small amphiphilic nanogels with tunable properties from a bioactive natural material (curcumin, with its well-known functionalities and health promoting activities) and a biocompatible maleic anhydride-based polymer. Our approach is based on a combination of chemical cross-linking, hydrophobic interaction and self-assembly. The nanogels were investigated for their physicochemical properties and colloidal stability under different pH values and salt concentrations as well as the in vitro cytotoxicity. The results indicated negative surface charge (as indicated by gel electrophoresis and laser Doppler anemometry with a zeta potential of − 60 mV) nanogels of small sizes (dh = 5.6 nm) with high colloidal stability at a wide range of pH values and NaCl concentrations. Additionally, the nanogels were not toxic up to concentration 100 μg/mL for BEAS-2B and A549 cells. The relatively facile preparation, high colloidal stability, ultra-small size and possible surface modification, functionalization and/or bioconjugation makes the obtained nanogels of great importance, especially in sensing and biomedical applications.
Keywords
- Amphiphilic polymer, Biocompatible, Curcumin, Nanogels, Sensing and biomedical, Surface functionalizable
ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemical Engineering(all)
- Engineering(all)
- Industrial and Manufacturing Engineering
- Materials Science(all)
- Materials Chemistry
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In: Chemical papers, Vol. 78, No. 1, 01.2024, p. 533-546.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Fabrication of surface-functionalizable amphiphilic curcumin nanogels for biosensing and biomedical applications
AU - Abdelmonem, Abuelmagd M.
AU - Lavrentieva, Antonina
AU - Bigall, Nadja C.
N1 - Funding Information: This paper is based upon work supported by Science, Technology & Innovation Funding Authority (STDF, Egypt) under the basic and applied science program (Grant no. 37041, STDF, Egypt). The authors would like to acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant agreement 714429), the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) under Germany’s excellence strategy within the cluster of excellence PhoenixD (EXC 2122, project ID 390833453 and the grant BI 1708/4-1) and Hannover School for Nanotechnology (hsn).
PY - 2024/1
Y1 - 2024/1
N2 - Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in recent years due to their attractive properties, especially in biomedical applications as delivery vehicle for therapeutic and diagnostic purposes. Here, we present a facile new synthetic strategy to prepare ultra-small amphiphilic nanogels with tunable properties from a bioactive natural material (curcumin, with its well-known functionalities and health promoting activities) and a biocompatible maleic anhydride-based polymer. Our approach is based on a combination of chemical cross-linking, hydrophobic interaction and self-assembly. The nanogels were investigated for their physicochemical properties and colloidal stability under different pH values and salt concentrations as well as the in vitro cytotoxicity. The results indicated negative surface charge (as indicated by gel electrophoresis and laser Doppler anemometry with a zeta potential of − 60 mV) nanogels of small sizes (dh = 5.6 nm) with high colloidal stability at a wide range of pH values and NaCl concentrations. Additionally, the nanogels were not toxic up to concentration 100 μg/mL for BEAS-2B and A549 cells. The relatively facile preparation, high colloidal stability, ultra-small size and possible surface modification, functionalization and/or bioconjugation makes the obtained nanogels of great importance, especially in sensing and biomedical applications.
AB - Nanogels, nanosized water-soluble physically and/or chemically cross-linked polymeric networks, have been widely prepared, characterized and studied in recent years due to their attractive properties, especially in biomedical applications as delivery vehicle for therapeutic and diagnostic purposes. Here, we present a facile new synthetic strategy to prepare ultra-small amphiphilic nanogels with tunable properties from a bioactive natural material (curcumin, with its well-known functionalities and health promoting activities) and a biocompatible maleic anhydride-based polymer. Our approach is based on a combination of chemical cross-linking, hydrophobic interaction and self-assembly. The nanogels were investigated for their physicochemical properties and colloidal stability under different pH values and salt concentrations as well as the in vitro cytotoxicity. The results indicated negative surface charge (as indicated by gel electrophoresis and laser Doppler anemometry with a zeta potential of − 60 mV) nanogels of small sizes (dh = 5.6 nm) with high colloidal stability at a wide range of pH values and NaCl concentrations. Additionally, the nanogels were not toxic up to concentration 100 μg/mL for BEAS-2B and A549 cells. The relatively facile preparation, high colloidal stability, ultra-small size and possible surface modification, functionalization and/or bioconjugation makes the obtained nanogels of great importance, especially in sensing and biomedical applications.
KW - Amphiphilic polymer
KW - Biocompatible
KW - Curcumin
KW - Nanogels
KW - Sensing and biomedical
KW - Surface functionalizable
UR - http://www.scopus.com/inward/record.url?scp=85173933911&partnerID=8YFLogxK
U2 - 10.1007/s11696-023-03108-4
DO - 10.1007/s11696-023-03108-4
M3 - Article
AN - SCOPUS:85173933911
VL - 78
SP - 533
EP - 546
JO - Chemical papers
JF - Chemical papers
SN - 0366-6352
IS - 1
ER -