Details
| Original language | English |
|---|---|
| Pages (from-to) | 4637-4647 |
| Number of pages | 11 |
| Journal | Nanophotonics |
| Volume | 11 |
| Issue number | 21 |
| Early online date | 26 Sept 2022 |
| Publication status | Published - Dec 2022 |
Abstract
The proper design of near-infrared light-absorbing agents enables efficient optoacoustic imaging-guided phototherapy. In particular, several croconaine-based organic agents with excellent optical properties have been recently reported for this purpose. However, most of them absorb light below 800 nm, limiting deep-tissue imaging applications. To this end, we utilized a recently described novel croconaine derivative (CR880) to develop CR880-based nanoparticles (CR880-NPs) for effective in vivo delivery, deep tissue optoacoustic imaging and photothermal therapy applications. Radicals and strong π-πstacking in CR880 result in an 880 nm absorption peak with no blue-shift upon condensing to the solid phase. DSPE-PEG2000-formulated CR880-NPs exhibited high optoacoustic generation efficiency and photostability, and could be visualized in the tumors of three different mouse tumor models (breast, brain, and colon tumor) with high image contrast. The high photothermal conversion efficiency of CR880-NPs (∼58%) subsequently enabled efficient in vivo tumor elimination using a low energy laser, while remaining biocompatible and well-tolerated. This work introduces a promising novel agent for cancer theranostics of challenging deep-seated tumors.
Keywords
- 880 nm, croconaine, deep tumors, nanoparticles, optoacoustics, photothermal therapy
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Engineering(all)
- Electrical and Electronic Engineering
Sustainable Development Goals
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In: Nanophotonics, Vol. 11, No. 21, 12.2022, p. 4637-4647.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy
AU - Liu, Nian
AU - O'Connor, Patrick
AU - Gujrati, Vipul
AU - Anzenhofer, Pia
AU - Klemm, Uwe
AU - Kleigrewe, Karin
AU - Sattler, Michael
AU - Plettenburg, Oliver
AU - Ntziachristos, Vasilis
N1 - Funding Information: Research funding: This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 694968 (PREMSOT). The research leading to these results was supported by the Deutsche Forschungsgemeinschaft (DFG), Germany (Gottfried Wilhelm Leibniz Prize 2013, NT 3/10–1) as well as by the DFG as part of the CRC 1123 (Z1). Dr. Nian Liu acknowledges support from the China Scholarship Council. Dr. Patrick O’Connor acknowledges support by the Helmholtz Association and the BMBF (16GW0251K). We wish to thank Carsten Peters (Department of Chemistry, Technical University of Munuch) for the TEM measurement, Dr. Juan Antonio Aguilar-Pimentel (German Mouse Clinic/Institute of Experimental Genetics, Helmholtz Zentrum München) for providing the thermal camera, Mohammed Azeem for assisting phantom preparation, and Dr. Doris Bengel for assisting with experimental procedures. We also wish to thank Dr. Sergey Sulima and Dr. Robert Wilson for helpful suggestions on the manuscript.
PY - 2022/12
Y1 - 2022/12
N2 - The proper design of near-infrared light-absorbing agents enables efficient optoacoustic imaging-guided phototherapy. In particular, several croconaine-based organic agents with excellent optical properties have been recently reported for this purpose. However, most of them absorb light below 800 nm, limiting deep-tissue imaging applications. To this end, we utilized a recently described novel croconaine derivative (CR880) to develop CR880-based nanoparticles (CR880-NPs) for effective in vivo delivery, deep tissue optoacoustic imaging and photothermal therapy applications. Radicals and strong π-πstacking in CR880 result in an 880 nm absorption peak with no blue-shift upon condensing to the solid phase. DSPE-PEG2000-formulated CR880-NPs exhibited high optoacoustic generation efficiency and photostability, and could be visualized in the tumors of three different mouse tumor models (breast, brain, and colon tumor) with high image contrast. The high photothermal conversion efficiency of CR880-NPs (∼58%) subsequently enabled efficient in vivo tumor elimination using a low energy laser, while remaining biocompatible and well-tolerated. This work introduces a promising novel agent for cancer theranostics of challenging deep-seated tumors.
AB - The proper design of near-infrared light-absorbing agents enables efficient optoacoustic imaging-guided phototherapy. In particular, several croconaine-based organic agents with excellent optical properties have been recently reported for this purpose. However, most of them absorb light below 800 nm, limiting deep-tissue imaging applications. To this end, we utilized a recently described novel croconaine derivative (CR880) to develop CR880-based nanoparticles (CR880-NPs) for effective in vivo delivery, deep tissue optoacoustic imaging and photothermal therapy applications. Radicals and strong π-πstacking in CR880 result in an 880 nm absorption peak with no blue-shift upon condensing to the solid phase. DSPE-PEG2000-formulated CR880-NPs exhibited high optoacoustic generation efficiency and photostability, and could be visualized in the tumors of three different mouse tumor models (breast, brain, and colon tumor) with high image contrast. The high photothermal conversion efficiency of CR880-NPs (∼58%) subsequently enabled efficient in vivo tumor elimination using a low energy laser, while remaining biocompatible and well-tolerated. This work introduces a promising novel agent for cancer theranostics of challenging deep-seated tumors.
KW - 880 nm
KW - croconaine
KW - deep tumors
KW - nanoparticles
KW - optoacoustics
KW - photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85139404740&partnerID=8YFLogxK
U2 - 10.1515/nanoph-2022-0469
DO - 10.1515/nanoph-2022-0469
M3 - Article
AN - SCOPUS:85139404740
VL - 11
SP - 4637
EP - 4647
JO - Nanophotonics
JF - Nanophotonics
SN - 2192-8606
IS - 21
ER -