Details
| Original language | English |
|---|---|
| Pages (from-to) | 1904-1917 |
| Number of pages | 14 |
| Journal | Current Pharmaceutical Design |
| Volume | 27 |
| Issue number | 16 |
| Early online date | 28 Jul 2020 |
| Publication status | Published - May 2021 |
Abstract
This review aims to highlight urgent priorities for the computational biomechanics community in the framework of mechano-chemo-biological models. Recent approaches, promising directions and open challenges on the computational modelling of arterial tissues in health and disease are introduced and investigated, together with in silico approaches for the analysis of drug-eluting stents that promote pharmacological-induced healing. The paper addresses a number of chemo-biological phenomena that are generally neglected in biomechanical engineering models but are most likely instrumental for the onset and the progression of arterial diseases. An interdisciplinary effort is thus encouraged for providing the tools for an effective in silico insight into medical problems. An integrated mechano-chemo-biological perspective is believed to be a fundamental missing piece for crossing the bridge between computational engineering and life sciences, and for bringing computational biome-chanics into medical research and clinical practice.
Keywords
- Arterial diseases, Computational biomechanics, Drug-eluting stents, Growth and remodelling, Mechano-chemo-biological models, Pharmacological-induced healing
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
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In: Current Pharmaceutical Design, Vol. 27, No. 16, 05.2021, p. 1904-1917.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Mechano-chemo-biological computational models for arteries in health, disease and healing
T2 - From tissue remodelling to drug-eluting devices
AU - Marino, Michele
AU - Vairo, Giuseppe
AU - Wriggers, Peter
N1 - Funding Information: M. Marino acknowledges that this work has been funded partially by the Masterplan SMART BIOTECS (Ministry of Science and Culture of Lower Saxony, Germany) and partially by the Rita Levi Montalcini Program for Young Researchers (Ministry of Education, University and Research, Italy).
PY - 2021/5
Y1 - 2021/5
N2 - This review aims to highlight urgent priorities for the computational biomechanics community in the framework of mechano-chemo-biological models. Recent approaches, promising directions and open challenges on the computational modelling of arterial tissues in health and disease are introduced and investigated, together with in silico approaches for the analysis of drug-eluting stents that promote pharmacological-induced healing. The paper addresses a number of chemo-biological phenomena that are generally neglected in biomechanical engineering models but are most likely instrumental for the onset and the progression of arterial diseases. An interdisciplinary effort is thus encouraged for providing the tools for an effective in silico insight into medical problems. An integrated mechano-chemo-biological perspective is believed to be a fundamental missing piece for crossing the bridge between computational engineering and life sciences, and for bringing computational biome-chanics into medical research and clinical practice.
AB - This review aims to highlight urgent priorities for the computational biomechanics community in the framework of mechano-chemo-biological models. Recent approaches, promising directions and open challenges on the computational modelling of arterial tissues in health and disease are introduced and investigated, together with in silico approaches for the analysis of drug-eluting stents that promote pharmacological-induced healing. The paper addresses a number of chemo-biological phenomena that are generally neglected in biomechanical engineering models but are most likely instrumental for the onset and the progression of arterial diseases. An interdisciplinary effort is thus encouraged for providing the tools for an effective in silico insight into medical problems. An integrated mechano-chemo-biological perspective is believed to be a fundamental missing piece for crossing the bridge between computational engineering and life sciences, and for bringing computational biome-chanics into medical research and clinical practice.
KW - Arterial diseases
KW - Computational biomechanics
KW - Drug-eluting stents
KW - Growth and remodelling
KW - Mechano-chemo-biological models
KW - Pharmacological-induced healing
UR - http://www.scopus.com/inward/record.url?scp=85108121634&partnerID=8YFLogxK
U2 - 10.2174/1381612826666200728145752
DO - 10.2174/1381612826666200728145752
M3 - Review article
C2 - 32723253
AN - SCOPUS:85108121634
VL - 27
SP - 1904
EP - 1917
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 16
ER -