Details
| Original language | English |
|---|---|
| Article number | 103825 |
| Journal | Journal of the Mechanical Behavior of Biomedical Materials |
| Volume | 109 |
| Early online date | 28 Apr 2020 |
| Publication status | Published - Sept 2020 |
Abstract
Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.
Keywords
- Bone substitute material, Degradation, In-vitro, In-vivo, Line-scan, Magnesium, Nanoindentation, Rabbit, Scanning electron microscope
ASJC Scopus subject areas
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
- Engineering(all)
- Mechanics of Materials
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In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 109, 103825, 09.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Investigation of degraded bone substitutes made of magnesium alloy using scanning electron microscope and nanoindentation
AU - Gartzke, Ann Kathrin
AU - Julmi, Stefan
AU - Klose, Christian
AU - Besdo, Silke
AU - Waselau, Anja Christina
AU - Meyer-Lindenberg, Andrea
AU - Maier, Hans-Jürgen
AU - Wriggers, Peter
N1 - Funding information: This research is supported by the German Research Foundation (DFG) within the project Interfacial effects and ingrowing behaviour of magnesium-based foams as bioresorbable bone substitute material” (grant no. 271761343 ). The authors gratefully acknowledge the support.
PY - 2020/9
Y1 - 2020/9
N2 - Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.
AB - Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.
KW - Bone substitute material
KW - Degradation
KW - In-vitro
KW - In-vivo
KW - Line-scan
KW - Magnesium
KW - Nanoindentation
KW - Rabbit
KW - Scanning electron microscope
UR - http://www.scopus.com/inward/record.url?scp=85085731761&partnerID=8YFLogxK
U2 - 10.1016/j.jmbbm.2020.103825
DO - 10.1016/j.jmbbm.2020.103825
M3 - Article
AN - SCOPUS:85085731761
VL - 109
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
SN - 1751-6161
M1 - 103825
ER -