Investigation of degraded bone substitutes made of magnesium alloy using scanning electron microscope and nanoindentation

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

Externe Organisationen

  • Ludwig-Maximilians-Universität München (LMU)
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Aufsatznummer103825
FachzeitschriftJournal of the Mechanical Behavior of Biomedical Materials
Jahrgang109
Frühes Online-Datum28 Apr. 2020
PublikationsstatusVeröffentlicht - Sept. 2020

Abstract

Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.

ASJC Scopus Sachgebiete

Zitieren

Investigation of degraded bone substitutes made of magnesium alloy using scanning electron microscope and nanoindentation. / Gartzke, Ann Kathrin; Julmi, Stefan; Klose, Christian et al.
in: Journal of the Mechanical Behavior of Biomedical Materials, Jahrgang 109, 103825, 09.2020.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Gartzke AK, Julmi S, Klose C, Besdo S, Waselau AC, Meyer-Lindenberg A et al. Investigation of degraded bone substitutes made of magnesium alloy using scanning electron microscope and nanoindentation. Journal of the Mechanical Behavior of Biomedical Materials. 2020 Sep;109:103825. Epub 2020 Apr 28. doi: 10.1016/j.jmbbm.2020.103825
Download
@article{21f61498a7c14ae6a1112849781ff861,
title = "Investigation of degraded bone substitutes made of magnesium alloy using scanning electron microscope and nanoindentation",
abstract = "Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.",
keywords = "Bone substitute material, Degradation, In-vitro, In-vivo, Line-scan, Magnesium, Nanoindentation, Rabbit, Scanning electron microscope",
author = "Gartzke, {Ann Kathrin} and Stefan Julmi and Christian Klose and Silke Besdo and Waselau, {Anja Christina} and Andrea Meyer-Lindenberg and Hans-J{\"u}rgen Maier and Peter Wriggers",
note = "Funding information: This research is supported by the German Research Foundation (DFG) within the project Interfacial effects and ingrowing behaviour of magnesium-based foams as bioresorbable bone substitute material” (grant no. 271761343 ). The authors gratefully acknowledge the support.",
year = "2020",
month = sep,
doi = "10.1016/j.jmbbm.2020.103825",
language = "English",
volume = "109",
journal = "Journal of the Mechanical Behavior of Biomedical Materials",
issn = "1751-6161",
publisher = "Elsevier BV",

}

Download

TY - JOUR

T1 - Investigation of degraded bone substitutes made of magnesium alloy using scanning electron microscope and nanoindentation

AU - Gartzke, Ann Kathrin

AU - Julmi, Stefan

AU - Klose, Christian

AU - Besdo, Silke

AU - Waselau, Anja Christina

AU - Meyer-Lindenberg, Andrea

AU - Maier, Hans-Jürgen

AU - Wriggers, Peter

N1 - Funding information: This research is supported by the German Research Foundation (DFG) within the project Interfacial effects and ingrowing behaviour of magnesium-based foams as bioresorbable bone substitute material” (grant no. 271761343 ). The authors gratefully acknowledge the support.

PY - 2020/9

Y1 - 2020/9

N2 - Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.

AB - Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.

KW - Bone substitute material

KW - Degradation

KW - In-vitro

KW - In-vivo

KW - Line-scan

KW - Magnesium

KW - Nanoindentation

KW - Rabbit

KW - Scanning electron microscope

UR - http://www.scopus.com/inward/record.url?scp=85085731761&partnerID=8YFLogxK

U2 - 10.1016/j.jmbbm.2020.103825

DO - 10.1016/j.jmbbm.2020.103825

M3 - Article

AN - SCOPUS:85085731761

VL - 109

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

SN - 1751-6161

M1 - 103825

ER -

Von denselben Autoren