Details
| Original language | English |
|---|---|
| Article number | 2090 |
| Journal | Polymers |
| Volume | 13 |
| Issue number | 13 |
| Publication status | Published - 24 Jun 2021 |
Abstract
Microstructural responses to the mechanical load of polymers used in tissue engineering is notably important for qualification at in vivo testing, although insufficiently studied, especially regarding promising polycaprolactone (PCL). For further investigations, electrospun PCL scaffolds with different degrees of fiber alignment were produced, using two discrete relative drum collector velocities. Development and preparation of an adjusted sample geometry enabled in situ tensile testing in scanning electron microscopy. By analyzing the microstructure and the use of selected tracking techniques, it was possible to visualize and quantify fiber/fiber area displacements as well as local fractures of single PCL fibers, considering quasi-static tensile load and fiber alignment. The possibility of displacement determination using in situ scanning electron microscopy techniques for testing fibrous PCL scaffolds was introduced and quantified.
Keywords
- Damage mechanisms, Electrospinning, Fiber orientation, In situ tensile testing, Microstructure, Polycaprolactone, Scanning electron microscopy, Tissue engineering
ASJC Scopus subject areas
- Chemistry(all)
- Materials Science(all)
- Polymers and Plastics
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In: Polymers, Vol. 13, No. 13, 2090, 24.06.2021.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - In situ characterization of polycaprolactone fiber response to quasi-static tensile loading in scanning electron microscopy
AU - Delp, Alexander
AU - Becker, Alexander
AU - Hülsbusch, Daniel
AU - Scholz, Ronja
AU - Müller, Marc
AU - Glasmacher, Birgit
AU - Walther, Frank
N1 - Funding Information: The research project is supported by the DFG in the framework of the Research Unit 2180 “Graded Implants for Tendon-Bone Junctions”. Acknowledgments: We acknowledge financial support by Deutsche Forschungsgemeinschaft and Technische Universität Dortmund/TU Dortmund University within the funding programme Open Access Publishing. We thank Michael Bode, Miriam Walter and Gioia Busse for their great support.
PY - 2021/6/24
Y1 - 2021/6/24
N2 - Microstructural responses to the mechanical load of polymers used in tissue engineering is notably important for qualification at in vivo testing, although insufficiently studied, especially regarding promising polycaprolactone (PCL). For further investigations, electrospun PCL scaffolds with different degrees of fiber alignment were produced, using two discrete relative drum collector velocities. Development and preparation of an adjusted sample geometry enabled in situ tensile testing in scanning electron microscopy. By analyzing the microstructure and the use of selected tracking techniques, it was possible to visualize and quantify fiber/fiber area displacements as well as local fractures of single PCL fibers, considering quasi-static tensile load and fiber alignment. The possibility of displacement determination using in situ scanning electron microscopy techniques for testing fibrous PCL scaffolds was introduced and quantified.
AB - Microstructural responses to the mechanical load of polymers used in tissue engineering is notably important for qualification at in vivo testing, although insufficiently studied, especially regarding promising polycaprolactone (PCL). For further investigations, electrospun PCL scaffolds with different degrees of fiber alignment were produced, using two discrete relative drum collector velocities. Development and preparation of an adjusted sample geometry enabled in situ tensile testing in scanning electron microscopy. By analyzing the microstructure and the use of selected tracking techniques, it was possible to visualize and quantify fiber/fiber area displacements as well as local fractures of single PCL fibers, considering quasi-static tensile load and fiber alignment. The possibility of displacement determination using in situ scanning electron microscopy techniques for testing fibrous PCL scaffolds was introduced and quantified.
KW - Damage mechanisms
KW - Electrospinning
KW - Fiber orientation
KW - In situ tensile testing
KW - Microstructure
KW - Polycaprolactone
KW - Scanning electron microscopy
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85109337006&partnerID=8YFLogxK
U2 - 10.3390/polym13132090
DO - 10.3390/polym13132090
M3 - Article
AN - SCOPUS:85109337006
VL - 13
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 13
M1 - 2090
ER -