An efficient one-pot three-component synthesis of tetrakis(uracil) and their corresponding bis-fused derivatives

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Amr M. Abdelmoniem
  • Said A.S. Ghozlan
  • Holger Butenschön
  • Doaa M. Abdelmoniem
  • Ahmed H.M. Elwahy
  • Ismail A. Abdelhamid

Research Organisations

External Research Organisations

  • Cairo University
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Details

Original languageEnglish
Pages (from-to)163-177
Number of pages15
JournalArkivoc
Volume2019
Issue number5
Early online date17 Mar 2019
Publication statusPublished - 2019

Abstract

A concise and efficient approach to tetrakis(uracil) derivatives by the reaction of bis(aldehydes) with four equivalents of 6-aminouracil is reported. Also, the synthesis of bis(pyrimido[4,5-b]quinolones) and bis(indeno-[2',1':5,6]pyrido[2,3-d]pyrimidine) derivatives has been accomplished by a three-component reaction involving bis(aldehydes), 6-aminouracil and the appropriate cyclic 1,3-diketone. The method involves domino Knoevenagel condensation / Michael addition reaction sequences.

Keywords

    Bis(aldehydes), Fused pyrimidines, Indenones, Michael addition, Quinolinones, Uracils

ASJC Scopus subject areas

Cite this

An efficient one-pot three-component synthesis of tetrakis(uracil) and their corresponding bis-fused derivatives. / Abdelmoniem, Amr M.; Ghozlan, Said A.S.; Butenschön, Holger et al.
In: Arkivoc, Vol. 2019, No. 5, 2019, p. 163-177.

Research output: Contribution to journalArticleResearchpeer review

Abdelmoniem AM, Ghozlan SAS, Butenschön H, Abdelmoniem DM, Elwahy AHM, Abdelhamid IA. An efficient one-pot three-component synthesis of tetrakis(uracil) and their corresponding bis-fused derivatives. Arkivoc. 2019;2019(5):163-177. Epub 2019 Mar 17. doi: 10.24820/ark.5550190.p010.875, 10.15488/11170
Abdelmoniem, Amr M. ; Ghozlan, Said A.S. ; Butenschön, Holger et al. / An efficient one-pot three-component synthesis of tetrakis(uracil) and their corresponding bis-fused derivatives. In: Arkivoc. 2019 ; Vol. 2019, No. 5. pp. 163-177.
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AU - Ghozlan, Said A.S.

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AU - Abdelmoniem, Doaa M.

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