Integrated ultrasound and photoacoustic tomography for 3D imaging of human skin lesions

Publikation: Beitrag in Buch/Bericht/Sammelwerk/KonferenzbandAufsatz in KonferenzbandForschungPeer-Review

Autoren

  • Anatoly Fedorov Kukk
  • Di Wu
  • Rüdiger Panzer
  • Steffen Emmert
  • Bernhard Roth
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Details

OriginalspracheEnglisch
Titel des SammelwerksAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII
Herausgeber/-innenCaroline Boudoux, James W. Tunnell
Herausgeber (Verlag)SPIE
Seitenumfang6
Band12831
ISBN (elektronisch)9781510669215
PublikationsstatusVeröffentlicht - 12 März 2024
VeranstaltungAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII 2024 - San Francisco, USA / Vereinigte Staaten
Dauer: 27 Jan. 202428 Jan. 2024

Publikationsreihe

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Band12831
ISSN (Print)1605-7422

Abstract

The rising incidence of skin cancer, in particular melanoma, highlights the need for improved detection techniques. Determining the maximal depth of a lesion is crucial for planning excision margins and optimizing treatment outcomes. However, the current gold standard diagnostics, such as excision and histological examination, are invasive, time-consuming, and may not accurately measure the deepest position of the lesion. Preoperative knowledge of lesion size and depth would greatly assist surgical planning and enhance the likelihood of achieving tumor-free excision margins. In this work, we report on an integrated imaging system that combines ultrasound (US) and photoacoustic tomography (PAT) into a single scanning unit, enabling fast and non-invasive co-localized measurements. Our system facilitates C-mode imaging, providing visualization of lesion depth across its entire size. The design of the setup offers a clear optical window, allowing for integration with other optical modalities. We conducted in vivo measurements on suspicious human skin nevi promptly followed by excision. The combined US/PAT imaging technique demonstrated a strong correlation with histological Breslow thickness, a key parameter for lesion depth. These results highlight the potential of combined US and PAT as a promising non-invasive 3D imaging approach for evaluating human nevi and other skin lesions. By correlating our imaging data with corresponding histological findings, we aim to increase the accuracy and demonstrate the clinical utility of the integrated ultrasound and photoacoustic tomography approach in non-invasive 3D imaging of human melanocytic and other skin lesions.

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Integrated ultrasound and photoacoustic tomography for 3D imaging of human skin lesions. / Kukk, Anatoly Fedorov; Wu, Di; Panzer, Rüdiger et al.
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII. Hrsg. / Caroline Boudoux; James W. Tunnell. Band 12831 SPIE, 2024. 128310G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Band 12831).

Publikation: Beitrag in Buch/Bericht/Sammelwerk/KonferenzbandAufsatz in KonferenzbandForschungPeer-Review

Kukk, AF, Wu, D, Panzer, R, Emmert, S & Roth, B 2024, Integrated ultrasound and photoacoustic tomography for 3D imaging of human skin lesions. in C Boudoux & JW Tunnell (Hrsg.), Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII. Bd. 12831, 128310G, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Bd. 12831, SPIE, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII 2024, San Francisco, USA / Vereinigte Staaten, 27 Jan. 2024. https://doi.org/10.1117/12.3001947
Kukk, A. F., Wu, D., Panzer, R., Emmert, S., & Roth, B. (2024). Integrated ultrasound and photoacoustic tomography for 3D imaging of human skin lesions. In C. Boudoux, & J. W. Tunnell (Hrsg.), Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII (Band 12831). Artikel 128310G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Band 12831). SPIE. https://doi.org/10.1117/12.3001947
Kukk AF, Wu D, Panzer R, Emmert S, Roth B. Integrated ultrasound and photoacoustic tomography for 3D imaging of human skin lesions. in Boudoux C, Tunnell JW, Hrsg., Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII. Band 12831. SPIE. 2024. 128310G. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.3001947
Kukk, Anatoly Fedorov ; Wu, Di ; Panzer, Rüdiger et al. / Integrated ultrasound and photoacoustic tomography for 3D imaging of human skin lesions. Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII. Hrsg. / Caroline Boudoux ; James W. Tunnell. Band 12831 SPIE, 2024. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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AU - Kukk, Anatoly Fedorov

AU - Wu, Di

AU - Panzer, Rüdiger

AU - Emmert, Steffen

AU - Roth, Bernhard

N1 - Publisher Copyright: © 2024 SPIE.

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