Correlative imaging and quantification of the tumor microenvironment of triple-negative-breast-cancer using lightsheet microscopy, scanning laser optical tomography, and TPEF

Publikation: Nicht-textuelle MedienAudiovisuelle VeröffentlichungForschung

Autoren

  • Hannes Kamin
  • Lena Nolte
  • Jochen Maurer
  • Elmar Stickeler
  • Dag Heinemann
  • Alexander Heisterkamp
  • Sonja Johannsmeier
  • T. Ripken

Externe Organisationen

  • Rheinisch-Westfälische Technische Hochschule Aachen (RWTH)
  • Laser Zentrum Hannover e.V. (LZH)
  • NIFE- Niedersächsisches Zentrum für Biomedizintechnik, Implantatforschung und Entwicklung
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Details

OriginalspracheEnglisch
Herausgeber (Verlag)SPIE
MediumOnline
PublikationsstatusVeröffentlicht - 6 März 2023
VeranstaltungSPIE BiOS 2023 - San Francisco, USA / Vereinigte Staaten
Dauer: 1 Feb. 20232 Feb. 2023

Abstract

The triple-negative breast cancer is an aggressive subtype that has a high rate of relapse and a poor five-year survival rate. The Tumor Microenviroment influences the behaviors such as proliferation, migration and the formation of metastasis. We present the complementary imaging and subsequent analysis of the Tumor Microenviroment using Lightsheet Microscopy, Scanning Laser Optical Tomography and TPEF. The samples were imaged in different size and resolution scales and the three-dimensional information is obtained using the SHG-signal of collagen and fluorescence of labeled key markers. The results presented here may help to create a patient specific model of breast cancer.

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Correlative imaging and quantification of the tumor microenvironment of triple-negative-breast-cancer using lightsheet microscopy, scanning laser optical tomography, and TPEF. Kamin, Hannes (Autor*in); Nolte, Lena (Autor*in); Maurer, Jochen (Autor*in) et al.. 2023. SPIEVeranstaltung: null, San Francisco, USA / Vereinigte Staaten.

Publikation: Nicht-textuelle MedienAudiovisuelle VeröffentlichungForschung

Kamin, Hannes (Autor*in) ; Nolte, Lena (Autor*in) ; Maurer, Jochen (Autor*in) et al.. / Correlative imaging and quantification of the tumor microenvironment of triple-negative-breast-cancer using lightsheet microscopy, scanning laser optical tomography, and TPEF. [Audiovisuelle Veröffentlichung].
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abstract = "The triple-negative breast cancer is an aggressive subtype that has a high rate of relapse and a poor five-year survival rate. The Tumor Microenviroment influences the behaviors such as proliferation, migration and the formation of metastasis. We present the complementary imaging and subsequent analysis of the Tumor Microenviroment using Lightsheet Microscopy, Scanning Laser Optical Tomography and TPEF. The samples were imaged in different size and resolution scales and the three-dimensional information is obtained using the SHG-signal of collagen and fluorescence of labeled key markers. The results presented here may help to create a patient specific model of breast cancer.",
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Download

TY - ADVS

T1 - Correlative imaging and quantification of the tumor microenvironment of triple-negative-breast-cancer using lightsheet microscopy, scanning laser optical tomography, and TPEF

AU - Kamin, Hannes

AU - Nolte, Lena

AU - Maurer, Jochen

AU - Stickeler, Elmar

AU - Heinemann, Dag

AU - Heisterkamp, Alexander

AU - Johannsmeier, Sonja

AU - Ripken, T.

PY - 2023/3/6

Y1 - 2023/3/6

N2 - The triple-negative breast cancer is an aggressive subtype that has a high rate of relapse and a poor five-year survival rate. The Tumor Microenviroment influences the behaviors such as proliferation, migration and the formation of metastasis. We present the complementary imaging and subsequent analysis of the Tumor Microenviroment using Lightsheet Microscopy, Scanning Laser Optical Tomography and TPEF. The samples were imaged in different size and resolution scales and the three-dimensional information is obtained using the SHG-signal of collagen and fluorescence of labeled key markers. The results presented here may help to create a patient specific model of breast cancer.

AB - The triple-negative breast cancer is an aggressive subtype that has a high rate of relapse and a poor five-year survival rate. The Tumor Microenviroment influences the behaviors such as proliferation, migration and the formation of metastasis. We present the complementary imaging and subsequent analysis of the Tumor Microenviroment using Lightsheet Microscopy, Scanning Laser Optical Tomography and TPEF. The samples were imaged in different size and resolution scales and the three-dimensional information is obtained using the SHG-signal of collagen and fluorescence of labeled key markers. The results presented here may help to create a patient specific model of breast cancer.

U2 - 10.1117/12.2648373

DO - 10.1117/12.2648373

M3 - Audiovisual publication

PB - SPIE

T2 - SPIE BiOS 2023

Y2 - 1 February 2023 through 2 February 2023

ER -

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