Details
| Original language | English |
|---|---|
| Pages (from-to) | 463-469 |
| Number of pages | 7 |
| Journal | Therapeutic Innovation & Regulatory Science |
| Volume | 31 |
| Issue number | 2 |
| Publication status | Published - 30 Dec 1997 |
Abstract
A trend test for dichotomous endpoints analogous to the nonparametric Jonckheere test is developed. The power of this and all other single trend tests for dichotomous endpoints strongly depends on the shape of the dose response curve. Combined tests which have a stable power over a wide range of the ordered alternative are suggested. One can combine several contrast tests to a so-called adjustive test which is more powerful than a Cochran-Armitage test with equally-spaced scores. The latter was recommended by Armitage (1) in case there is no a priori knowledge of the type of the trend.
Keywords
- Carcinogenicity studies, Dichotomous endpoints, Order restricted alternative, Trend tests, Unknown shape
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Medicine(all)
- Pharmacology (medical)
Sustainable Development Goals
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In: Therapeutic Innovation & Regulatory Science, Vol. 31, No. 2, 30.12.1997, p. 463-469.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Trend tests for dichotomous endpoints with application to carcinogenicity studies
AU - Neuhäuser, Markus
AU - Hothorn, Ludwig A.
PY - 1997/12/30
Y1 - 1997/12/30
N2 - A trend test for dichotomous endpoints analogous to the nonparametric Jonckheere test is developed. The power of this and all other single trend tests for dichotomous endpoints strongly depends on the shape of the dose response curve. Combined tests which have a stable power over a wide range of the ordered alternative are suggested. One can combine several contrast tests to a so-called adjustive test which is more powerful than a Cochran-Armitage test with equally-spaced scores. The latter was recommended by Armitage (1) in case there is no a priori knowledge of the type of the trend.
AB - A trend test for dichotomous endpoints analogous to the nonparametric Jonckheere test is developed. The power of this and all other single trend tests for dichotomous endpoints strongly depends on the shape of the dose response curve. Combined tests which have a stable power over a wide range of the ordered alternative are suggested. One can combine several contrast tests to a so-called adjustive test which is more powerful than a Cochran-Armitage test with equally-spaced scores. The latter was recommended by Armitage (1) in case there is no a priori knowledge of the type of the trend.
KW - Carcinogenicity studies
KW - Dichotomous endpoints
KW - Order restricted alternative
KW - Trend tests
KW - Unknown shape
UR - http://www.scopus.com/inward/record.url?scp=84993736054&partnerID=8YFLogxK
U2 - 10.1177/009286159703100217
DO - 10.1177/009286159703100217
M3 - Article
AN - SCOPUS:84993736054
VL - 31
SP - 463
EP - 469
JO - Therapeutic Innovation & Regulatory Science
JF - Therapeutic Innovation & Regulatory Science
SN - 2168-4790
IS - 2
ER -