Details
| Original language | English |
|---|---|
| Pages (from-to) | 137-146 |
| Number of pages | 10 |
| Journal | Journal of Drug Delivery Science and Technology |
| Volume | 31 |
| Early online date | 4 Jan 2016 |
| Publication status | Published - Feb 2016 |
Abstract
The unique properties of fibers have received great attention from the scientific community as suitable candidates for biomedical engineering and drug delivery applications. Their properties include, high surface-to-volume ratio, high porosity, adjustable pore size and morphological similarity to the extracellular matrix. Polymeric fibrous structures have been recognized as drug-delivery system candidates and various techniques have been employed to tailor-made their characteristics, such as the electro-hydrodynamic techniques (EHD). The latter methods exploit the electrostatic forces in order to create particles or fibers of tunable microstructure. One of the most important EHD is electrospinning, which is a cost-efficient method to fabricate fibers, either in the laboratory or in the industrial scale. Electrospinning realizes the direct encapsulation of pharmaceutical agents or biomolecules in the fibers, protecting them from the surrounding environment while at the same time controlling their release. Coaxial electrospinning is a modification of the process, which enables the creation of structures with core-shell fiber morphology. Numerous scientific studies have indicated the capability of electrospun fibers to be used as drug delivery systems (DDSs). The main aim of this review is to summarize the basic principles of electrospinning as well as the most recent developments regarding biomedical engineering, focusing on drug delivery.
Keywords
- Biomaterials, Biomedical engineering, Controlled drug delivery, Core-shell fibers, Polycaprolactone, Polymers
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
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In: Journal of Drug Delivery Science and Technology, Vol. 31, 02.2016, p. 137-146.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - The significance of electrospinning as a method to create fibrous scaffolds for biomedical engineering and drug delivery applications
AU - Repanas, Alexandros
AU - Andriopoulou, Sofia
AU - Glasmacher, Birgit
N1 - Funding Information: This research was partly granted by the Deutsche Forschungsgemeinschaft (DFG) through the Cluster of Excellence REBIRTH ( DFG EXC 62/1 ).
PY - 2016/2
Y1 - 2016/2
N2 - The unique properties of fibers have received great attention from the scientific community as suitable candidates for biomedical engineering and drug delivery applications. Their properties include, high surface-to-volume ratio, high porosity, adjustable pore size and morphological similarity to the extracellular matrix. Polymeric fibrous structures have been recognized as drug-delivery system candidates and various techniques have been employed to tailor-made their characteristics, such as the electro-hydrodynamic techniques (EHD). The latter methods exploit the electrostatic forces in order to create particles or fibers of tunable microstructure. One of the most important EHD is electrospinning, which is a cost-efficient method to fabricate fibers, either in the laboratory or in the industrial scale. Electrospinning realizes the direct encapsulation of pharmaceutical agents or biomolecules in the fibers, protecting them from the surrounding environment while at the same time controlling their release. Coaxial electrospinning is a modification of the process, which enables the creation of structures with core-shell fiber morphology. Numerous scientific studies have indicated the capability of electrospun fibers to be used as drug delivery systems (DDSs). The main aim of this review is to summarize the basic principles of electrospinning as well as the most recent developments regarding biomedical engineering, focusing on drug delivery.
AB - The unique properties of fibers have received great attention from the scientific community as suitable candidates for biomedical engineering and drug delivery applications. Their properties include, high surface-to-volume ratio, high porosity, adjustable pore size and morphological similarity to the extracellular matrix. Polymeric fibrous structures have been recognized as drug-delivery system candidates and various techniques have been employed to tailor-made their characteristics, such as the electro-hydrodynamic techniques (EHD). The latter methods exploit the electrostatic forces in order to create particles or fibers of tunable microstructure. One of the most important EHD is electrospinning, which is a cost-efficient method to fabricate fibers, either in the laboratory or in the industrial scale. Electrospinning realizes the direct encapsulation of pharmaceutical agents or biomolecules in the fibers, protecting them from the surrounding environment while at the same time controlling their release. Coaxial electrospinning is a modification of the process, which enables the creation of structures with core-shell fiber morphology. Numerous scientific studies have indicated the capability of electrospun fibers to be used as drug delivery systems (DDSs). The main aim of this review is to summarize the basic principles of electrospinning as well as the most recent developments regarding biomedical engineering, focusing on drug delivery.
KW - Biomaterials
KW - Biomedical engineering
KW - Controlled drug delivery
KW - Core-shell fibers
KW - Polycaprolactone
KW - Polymers
UR - http://www.scopus.com/inward/record.url?scp=84957590544&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2015.12.007
DO - 10.1016/j.jddst.2015.12.007
M3 - Review article
AN - SCOPUS:84957590544
VL - 31
SP - 137
EP - 146
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
SN - 1773-2247
ER -