Details
| Original language | English |
|---|---|
| Pages (from-to) | 2133-2146 |
| Number of pages | 14 |
| Journal | Statistics in medicine |
| Volume | 17 |
| Issue number | 18 |
| Early online date | 21 Dec 1998 |
| Publication status | E-pub ahead of print - 21 Dec 1998 |
Abstract
Inferential test strategies for multi-arm trials are adapted or proposed for the special situation when more than one dose of a test treatment, placebo and active control(s) are compared. This includes between doses, dose-placebo and dose-active-control comparisons. The procedures refer to situations when detailed comparisons make sense only if the sensitivity of the trial has been shown, for example, if a dose-response relationship or a difference between active control and placebo has been established. Split strategies, hierarchical (assuming an order restriction among doses) or linked procedures are introduced. In linked procedures, equivalence to the active control will be established only if the dose is also shown to be effective as compared to placebo. All the inferential procedures control the experimentwise error rate in the strong sense for the respective sets of null hypotheses considered.
ASJC Scopus subject areas
- Medicine(all)
- Epidemiology
- Mathematics(all)
- Statistics and Probability
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In: Statistics in medicine, Vol. 17, No. 18, 21.12.1998, p. 2133-2146.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Testing strategies in multi-dose experiments including active control
AU - Bauer, P.
AU - Röhmel, J.
AU - Maurer, W.
AU - Hothorn, L.
PY - 1998/12/21
Y1 - 1998/12/21
N2 - Inferential test strategies for multi-arm trials are adapted or proposed for the special situation when more than one dose of a test treatment, placebo and active control(s) are compared. This includes between doses, dose-placebo and dose-active-control comparisons. The procedures refer to situations when detailed comparisons make sense only if the sensitivity of the trial has been shown, for example, if a dose-response relationship or a difference between active control and placebo has been established. Split strategies, hierarchical (assuming an order restriction among doses) or linked procedures are introduced. In linked procedures, equivalence to the active control will be established only if the dose is also shown to be effective as compared to placebo. All the inferential procedures control the experimentwise error rate in the strong sense for the respective sets of null hypotheses considered.
AB - Inferential test strategies for multi-arm trials are adapted or proposed for the special situation when more than one dose of a test treatment, placebo and active control(s) are compared. This includes between doses, dose-placebo and dose-active-control comparisons. The procedures refer to situations when detailed comparisons make sense only if the sensitivity of the trial has been shown, for example, if a dose-response relationship or a difference between active control and placebo has been established. Split strategies, hierarchical (assuming an order restriction among doses) or linked procedures are introduced. In linked procedures, equivalence to the active control will be established only if the dose is also shown to be effective as compared to placebo. All the inferential procedures control the experimentwise error rate in the strong sense for the respective sets of null hypotheses considered.
UR - http://www.scopus.com/inward/record.url?scp=0032582081&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0258(19980930)17:18<2133::AID-SIM901>3.0.CO;2-2
DO - 10.1002/(SICI)1097-0258(19980930)17:18<2133::AID-SIM901>3.0.CO;2-2
M3 - Article
C2 - 9789919
AN - SCOPUS:0032582081
VL - 17
SP - 2133
EP - 2146
JO - Statistics in medicine
JF - Statistics in medicine
SN - 0277-6715
IS - 18
ER -