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TAL effectors are remote controls for gene activation

Research output: Contribution to journalReview articleResearchpeer review

Authors

  • Heidi Scholze
  • Jens Boch

External Research Organisations

  • Martin Luther University Halle-Wittenberg

Details

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalCurrent Opinion in Microbiology
Volume14
Issue number1
Publication statusPublished - Feb 2011
Externally publishedYes

Abstract

TAL (transcription activator- like) effectors constitute a novel class of DNA-binding proteins with predictable specificity. They are employed by Gram-negative plant-pathogenic bacteria of the genus Xanthomonas which translocate a cocktail of different effector proteins via a type III secretion system (T3SS) into plant cells where they serve as virulence determinants. Inside the plant cell, TALs localize to the nucleus, bind to target promoters, and induce expression of plant genes. DNA-binding specificity of TALs is determined by a central domain of tandem repeats. Each repeat confers recognition of one base pair (bp) in the DNA. Rearrangement of repeat modules allows design of proteins with desired DNA-binding specificities. Here, we summarize how TAL specificity is encoded, first structural data and first data on site-specific TAL nucleases.

ASJC Scopus subject areas

Sustainable Development Goals

Cite this

TAL effectors are remote controls for gene activation. / Scholze, Heidi; Boch, Jens.
In: Current Opinion in Microbiology, Vol. 14, No. 1, 02.2011, p. 47-53.

Research output: Contribution to journalReview articleResearchpeer review

Scholze H, Boch J. TAL effectors are remote controls for gene activation. Current Opinion in Microbiology. 2011 Feb;14(1):47-53. doi: 10.1016/j.mib.2010.12.001
Scholze, Heidi ; Boch, Jens. / TAL effectors are remote controls for gene activation. In: Current Opinion in Microbiology. 2011 ; Vol. 14, No. 1. pp. 47-53.
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