Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females

Research output: Working paper/Preprint › Preprint

Authors

  • Ludwig A. Hothorn

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Original languageEnglish
Publication statusE-pub ahead of print - 10 Nov 2020

Abstract

The separate evaluation for males and females is the recent standard in in-vivo toxicology for dose or treatment effects using Dunnett tests. The alternative pre-test for sex-by-treatment interaction is problematic. Here a joint test is proposed considering the two sex-specific and the pooled Dunnett-type comparisons. The calculation of either simultaneous confidence intervals or adjusted p-values with the R-package multcomp is demonstrated using a real data example.

Keywords

    stat.AP

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Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females. / Hothorn, Ludwig A.
2020.

Research output: Working paper/Preprint › Preprint

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