Details
| Original language | English |
|---|---|
| Article number | 438 |
| Journal | CRYSTALS |
| Volume | 10 |
| Issue number | 6 |
| Publication status | Published - 29 May 2020 |
Abstract
In patients with severe heart failure, the surgical reconstruction of the damaged myocardium with regenerative biological grafts is an innovative therapeutic option. However, natural patch materials are often too delicate for a full wall repair of the left ventricle. A degradable magnesium scaffold could provide temporary mechanical stability until the sufficient physiological remodeling of such grafts. An autologous vascularised gastric patch was employed for the reconstruction of the left ventricular myocardium in a porcine model. Magnesium alloy (LA63) scaffolds were fixed over the biological patch. The function of the implant was assessed via magnetic resonance imaging. Angiography was carried out to detect a connection between the gastric and coronary vasculature. The explants were examined via µ-computer tomography and light microscopy. All the test animals survived. The prostheses integrated biologically and functionally into the myocardium. No rupture of the prostheses occurred. An anastomosis of the gastric and coronary vasculature had developed. The magnesium scaffolds degraded, on average, to 30.9% of their original volume. This novel technique responds to the increasing demand for regenerative myocardial grafts. The magnesium scaffolds’ biocompatibility and degradation kinetics, as well as their stabilizing effects, indicate their applicability in the surgical treatment of terminal heart failure.
Keywords
- Cardiac surgery, Degradation kinetics of magnesium, Magnesium scaffolds, Myocardial prosthesis, Regenerative therapy, Terminal heart failure
ASJC Scopus subject areas
- Chemical Engineering(all)
- General Chemical Engineering
- Materials Science(all)
- General Materials Science
- Physics and Astronomy(all)
- Condensed Matter Physics
- Chemistry(all)
- Inorganic Chemistry
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In: CRYSTALS, Vol. 10, No. 6, 438, 29.05.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Stabilisation of a Segment of Autologous Vascularised Stomach as a Patch for Myocardial Reconstruction with Degradable Magnesium Alloy Scaffolds in a Swine Model
AU - Schilling, Tobias
AU - Bauer, Michael
AU - Hartung, Dagmar
AU - Brandes, Gudrun
AU - Tudorache, Igor
AU - Cebotari, Serghei
AU - Meyer, Tanja
AU - Wacker, Frank
AU - Haverich, Axel
AU - Hassel, Thomas
N1 - Funding information: This research was funded by German Research Foundation, SFB599, project R7. The excellent technical support of Klaus Höffler, Petra Ziehme, Astrid Dierks-Ketterkat, and Rosi Katt of the Department of Cardiovascular, Thoracic, and Transplantation Surgery, as well as Annette Oestereich and Frank Schröder of the Institute for Radiology of Hannover Medical School is highly appreciated. We also thank Luigi Angrisani and Dr. Christoph Klose of the Institut für Werkstoffkunde (Materials Science) of Leibniz Universität Hannover for facilitating the µ-CT investigations. Not least, we are grateful to Prof. Andre Bleich, Prof. Klaus Otto, Karl-Heinz Napierski, and Paul Zerbe of the central animal facility of Hannover Medical School for their competent support in performing the animal surgery and providing the excellent laboratory infrastructure. Finally, we are grateful to the German Research Foundation for funding this project. Funding: This research was funded by German Research Foundation, SFB599, project R7.
PY - 2020/5/29
Y1 - 2020/5/29
N2 - In patients with severe heart failure, the surgical reconstruction of the damaged myocardium with regenerative biological grafts is an innovative therapeutic option. However, natural patch materials are often too delicate for a full wall repair of the left ventricle. A degradable magnesium scaffold could provide temporary mechanical stability until the sufficient physiological remodeling of such grafts. An autologous vascularised gastric patch was employed for the reconstruction of the left ventricular myocardium in a porcine model. Magnesium alloy (LA63) scaffolds were fixed over the biological patch. The function of the implant was assessed via magnetic resonance imaging. Angiography was carried out to detect a connection between the gastric and coronary vasculature. The explants were examined via µ-computer tomography and light microscopy. All the test animals survived. The prostheses integrated biologically and functionally into the myocardium. No rupture of the prostheses occurred. An anastomosis of the gastric and coronary vasculature had developed. The magnesium scaffolds degraded, on average, to 30.9% of their original volume. This novel technique responds to the increasing demand for regenerative myocardial grafts. The magnesium scaffolds’ biocompatibility and degradation kinetics, as well as their stabilizing effects, indicate their applicability in the surgical treatment of terminal heart failure.
AB - In patients with severe heart failure, the surgical reconstruction of the damaged myocardium with regenerative biological grafts is an innovative therapeutic option. However, natural patch materials are often too delicate for a full wall repair of the left ventricle. A degradable magnesium scaffold could provide temporary mechanical stability until the sufficient physiological remodeling of such grafts. An autologous vascularised gastric patch was employed for the reconstruction of the left ventricular myocardium in a porcine model. Magnesium alloy (LA63) scaffolds were fixed over the biological patch. The function of the implant was assessed via magnetic resonance imaging. Angiography was carried out to detect a connection between the gastric and coronary vasculature. The explants were examined via µ-computer tomography and light microscopy. All the test animals survived. The prostheses integrated biologically and functionally into the myocardium. No rupture of the prostheses occurred. An anastomosis of the gastric and coronary vasculature had developed. The magnesium scaffolds degraded, on average, to 30.9% of their original volume. This novel technique responds to the increasing demand for regenerative myocardial grafts. The magnesium scaffolds’ biocompatibility and degradation kinetics, as well as their stabilizing effects, indicate their applicability in the surgical treatment of terminal heart failure.
KW - Cardiac surgery
KW - Degradation kinetics of magnesium
KW - Magnesium scaffolds
KW - Myocardial prosthesis
KW - Regenerative therapy
KW - Terminal heart failure
UR - http://www.scopus.com/inward/record.url?scp=85085711096&partnerID=8YFLogxK
U2 - 10.3390/cryst10060438
DO - 10.3390/cryst10060438
M3 - Article
AN - SCOPUS:85085711096
VL - 10
JO - CRYSTALS
JF - CRYSTALS
SN - 2073-4352
IS - 6
M1 - 438
ER -