Details
| Original language | English |
|---|---|
| Title of host publication | Single-Use Technology in Biopharmaceutical Manufacture |
| Editors | Regine Eibl, Dieter Eibl |
| Publisher | Wiley-Blackwell |
| Chapter | 6 |
| Pages | 69-82 |
| Number of pages | 14 |
| Edition | 2. |
| ISBN (electronic) | 9781119477891 |
| ISBN (print) | 9781119477839 |
| Publication status | Published - 5 Aug 2019 |
Abstract
This chapter provides an overview on the available and future sensor technology for single-use bioreactors. A bioreactor can be considered to be a three-phase system, consisting of a liquid, gas, and solid phase (cells). Sensors for monitoring each of these phases exist. However, because of their relevance for disposable bioreactors, the chapter is constrained to sensors for liquid-phase analysis. In the case of liquid-phase online measurements, one can distinguish invasive from noninvasive sensors. Invasive sensors are in direct contact with the cultivation medium, whereas noninvasive systems preserve the integrity of the sterile barrier of the reactor. Optical chemosensors (optodes) enable in situ measurements and can be used as online monitoring devices. Most optodes work with a disposable sensing part and reusable connection and readout unit. Optical chemosensors can easily be integrated into disposable bioreactor systems. The optical window concept can also be used for spectroscopic sensors.
Keywords
- Disposable bioreactor systems, In situ measurements, Invasive sensors, Liquid-phase analysis, Noninvasive sensors, Optical chemosensors, Single-use bioreactors, Spectroscopic sensors
ASJC Scopus subject areas
- Medicine(all)
- General Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
- Biochemistry, Genetics and Molecular Biology(all)
- General Biochemistry,Genetics and Molecular Biology
- Engineering(all)
- General Engineering
- Chemical Engineering(all)
- General Chemical Engineering
Cite this
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Single-Use Technology in Biopharmaceutical Manufacture. ed. / Regine Eibl; Dieter Eibl. 2. ed. Wiley-Blackwell, 2019. p. 69-82.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Sensors for disposable bioreactor systems
AU - Steinwedel, Tobias
AU - Dahlmann, Katharina
AU - Solle, Dörte
AU - Scheper, Thomas
AU - Reardon, Kenneth F.
AU - Lammers, Frank
PY - 2019/8/5
Y1 - 2019/8/5
N2 - This chapter provides an overview on the available and future sensor technology for single-use bioreactors. A bioreactor can be considered to be a three-phase system, consisting of a liquid, gas, and solid phase (cells). Sensors for monitoring each of these phases exist. However, because of their relevance for disposable bioreactors, the chapter is constrained to sensors for liquid-phase analysis. In the case of liquid-phase online measurements, one can distinguish invasive from noninvasive sensors. Invasive sensors are in direct contact with the cultivation medium, whereas noninvasive systems preserve the integrity of the sterile barrier of the reactor. Optical chemosensors (optodes) enable in situ measurements and can be used as online monitoring devices. Most optodes work with a disposable sensing part and reusable connection and readout unit. Optical chemosensors can easily be integrated into disposable bioreactor systems. The optical window concept can also be used for spectroscopic sensors.
AB - This chapter provides an overview on the available and future sensor technology for single-use bioreactors. A bioreactor can be considered to be a three-phase system, consisting of a liquid, gas, and solid phase (cells). Sensors for monitoring each of these phases exist. However, because of their relevance for disposable bioreactors, the chapter is constrained to sensors for liquid-phase analysis. In the case of liquid-phase online measurements, one can distinguish invasive from noninvasive sensors. Invasive sensors are in direct contact with the cultivation medium, whereas noninvasive systems preserve the integrity of the sterile barrier of the reactor. Optical chemosensors (optodes) enable in situ measurements and can be used as online monitoring devices. Most optodes work with a disposable sensing part and reusable connection and readout unit. Optical chemosensors can easily be integrated into disposable bioreactor systems. The optical window concept can also be used for spectroscopic sensors.
KW - Disposable bioreactor systems
KW - In situ measurements
KW - Invasive sensors
KW - Liquid-phase analysis
KW - Noninvasive sensors
KW - Optical chemosensors
KW - Single-use bioreactors
KW - Spectroscopic sensors
UR - http://www.scopus.com/inward/record.url?scp=85103004518&partnerID=8YFLogxK
U2 - 10.1002/9781119477891.ch6
DO - 10.1002/9781119477891.ch6
M3 - Contribution to book/anthology
AN - SCOPUS:85103004518
SN - 9781119477839
SP - 69
EP - 82
BT - Single-Use Technology in Biopharmaceutical Manufacture
A2 - Eibl, Regine
A2 - Eibl, Dieter
PB - Wiley-Blackwell
ER -