Details
| Original language | English |
|---|---|
| Pages (from-to) | 1073-1086 |
| Number of pages | 14 |
| Journal | Materials Science and Engineering C |
| Volume | 98 |
| Early online date | 21 Jan 2019 |
| Publication status | Published - May 2019 |
Abstract
Large bone defects or fractures must be treated with an implant or transplant. Resorbable implants are attractive as these require only one surgery, whereas bone autografts, which can be cut off from the same person's hip, require more than one procedure. Moreover, porous structures promote the ingrowth of the patient's bone. Thus, the objective of the present study was to develop open-pored biodegradable implant structures with different pore sizes that provide for both adequate degradation behaviour and mechanical properties that match with those of bone. The magnesium alloys LAE442 and La2 were employed in this study, as these materials are known to feature good biocompatibility and mechanical properties close to bone. It was possible to cast magnesium sponges with different pore sizes using the alloy LAE442. However, with the Mg–La2 alloy, only sponges with a minimum pore size of 0.5 mm could be produced. Overall, the sponges cast with the LAE442 alloy showed higher strength, even though the strengths of the dense parts were similar in both alloys tested. In terms of castability and mechanical behaviour, the LAE442 alloy turned out to be more favourable. In order to adapt the implant degradation behaviour to the bone ingrowth behaviour, coating of the magnesium sponges with calcium phosphate and polylactic acid was also investigated. Additionally, the different coatings were tested on their adhesive forces and influences to the in-vitro degradation behaviour.
Keywords
- Biocompatible magnesium alloys, Coating, Investment casting, Magnesium sponges, Resorbable implants, Magnesium/chemistry, Biocompatible Materials/chemistry, Bone and Bones/metabolism, Humans, Calcium Phosphates/chemistry, Absorbable Implants, Alloys/chemistry, Bone Transplantation/methods, Materials Testing/methods, Porosity
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Condensed Matter Physics
- Engineering(all)
- Mechanics of Materials
- Engineering(all)
- Mechanical Engineering
- Materials Science(all)
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In: Materials Science and Engineering C, Vol. 98, 05.2019, p. 1073-1086.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Processing and coating of open-pored absorbable magnesium-based bone implants
AU - Julmi, Stefan
AU - Krüger, Ann Kathrin
AU - Waselau, Anja Christina
AU - Meyer-Lindenberg, Andrea
AU - Wriggers, Peter
AU - Klose, Christian
AU - Maier, Hans Jürgen
N1 - Funding Information: This research was supported by the German Research Foundation (DFG) within the project “Interfacial effects and ingrowing behaviour of magnesium-based foams as bioresorbable bone substitute material” (grant No. MA 1175/52-1, ME 1941/3-1 and WR 19/56-1; 271761343). The Xradia 520 Versa (grant No. MA1175/67-1; 316923185) that has been used in this study, was sponsored by the DFG.
PY - 2019/5
Y1 - 2019/5
N2 - Large bone defects or fractures must be treated with an implant or transplant. Resorbable implants are attractive as these require only one surgery, whereas bone autografts, which can be cut off from the same person's hip, require more than one procedure. Moreover, porous structures promote the ingrowth of the patient's bone. Thus, the objective of the present study was to develop open-pored biodegradable implant structures with different pore sizes that provide for both adequate degradation behaviour and mechanical properties that match with those of bone. The magnesium alloys LAE442 and La2 were employed in this study, as these materials are known to feature good biocompatibility and mechanical properties close to bone. It was possible to cast magnesium sponges with different pore sizes using the alloy LAE442. However, with the Mg–La2 alloy, only sponges with a minimum pore size of 0.5 mm could be produced. Overall, the sponges cast with the LAE442 alloy showed higher strength, even though the strengths of the dense parts were similar in both alloys tested. In terms of castability and mechanical behaviour, the LAE442 alloy turned out to be more favourable. In order to adapt the implant degradation behaviour to the bone ingrowth behaviour, coating of the magnesium sponges with calcium phosphate and polylactic acid was also investigated. Additionally, the different coatings were tested on their adhesive forces and influences to the in-vitro degradation behaviour.
AB - Large bone defects or fractures must be treated with an implant or transplant. Resorbable implants are attractive as these require only one surgery, whereas bone autografts, which can be cut off from the same person's hip, require more than one procedure. Moreover, porous structures promote the ingrowth of the patient's bone. Thus, the objective of the present study was to develop open-pored biodegradable implant structures with different pore sizes that provide for both adequate degradation behaviour and mechanical properties that match with those of bone. The magnesium alloys LAE442 and La2 were employed in this study, as these materials are known to feature good biocompatibility and mechanical properties close to bone. It was possible to cast magnesium sponges with different pore sizes using the alloy LAE442. However, with the Mg–La2 alloy, only sponges with a minimum pore size of 0.5 mm could be produced. Overall, the sponges cast with the LAE442 alloy showed higher strength, even though the strengths of the dense parts were similar in both alloys tested. In terms of castability and mechanical behaviour, the LAE442 alloy turned out to be more favourable. In order to adapt the implant degradation behaviour to the bone ingrowth behaviour, coating of the magnesium sponges with calcium phosphate and polylactic acid was also investigated. Additionally, the different coatings were tested on their adhesive forces and influences to the in-vitro degradation behaviour.
KW - Biocompatible magnesium alloys
KW - Coating
KW - Investment casting
KW - Magnesium sponges
KW - Resorbable implants
KW - Magnesium/chemistry
KW - Biocompatible Materials/chemistry
KW - Bone and Bones/metabolism
KW - Humans
KW - Calcium Phosphates/chemistry
KW - Absorbable Implants
KW - Alloys/chemistry
KW - Bone Transplantation/methods
KW - Materials Testing/methods
KW - Porosity
UR - http://www.scopus.com/inward/record.url?scp=85060230928&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2018.12.125
DO - 10.1016/j.msec.2018.12.125
M3 - Article
C2 - 30812991
AN - SCOPUS:85060230928
VL - 98
SP - 1073
EP - 1086
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
ER -