Details
Original language | English |
---|---|
Title of host publication | Industrial Enzyme Applications |
Publisher | Wiley-VCH Verlag |
Pages | 71-94 |
Number of pages | 24 |
ISBN (electronic) | 9783527813759 |
ISBN (print) | 9783527343850 |
Publication status | Published - 29 Apr 2019 |
Externally published | Yes |
Abstract
Enzymes are typically the catalyst of choice when high atom efficiency and high selectivity are desired. However, the use of enzymes for organic synthesis represents a multiparameter challenge. Development of efficient enzymatic reactions necessitates careful evaluation of three parameters: (i) reaction of interest (solubility of substrates/products, reaction medium, thermodynamic equilibrium), (ii) biocatalyst (activity, stability, substrate/product inhibition), and (iii) process (catalyst preparation, reactor type, operation mode). This chapter focuses on these parameters as well as assessment of criteria to be considered for the application of enzymes in an industrial environment.
Keywords
- Biocatalysis, Bioprocess development, Immobilization, Multiphase reactions, Reaction engineering, Reactor types, Rules of thumb in biocatalysis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- General Biochemistry,Genetics and Molecular Biology
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
Industrial Enzyme Applications. Wiley-VCH Verlag, 2019. p. 71-94.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Process considerations for the application of enzymes
AU - Kara, Selin
AU - Liese, Andreas
N1 - Funding Information: We acknowledge useful discussions with Julianne Dalcanton, Ray Weymann, Ted Williams, Ann Zabludoff, and Dennis Zaritsky. This research was supported in part by NASA grant NAG 5-2831. J. S. M. acknowledges support from a Carnegie postdoctoral fellowship.
PY - 2019/4/29
Y1 - 2019/4/29
N2 - Enzymes are typically the catalyst of choice when high atom efficiency and high selectivity are desired. However, the use of enzymes for organic synthesis represents a multiparameter challenge. Development of efficient enzymatic reactions necessitates careful evaluation of three parameters: (i) reaction of interest (solubility of substrates/products, reaction medium, thermodynamic equilibrium), (ii) biocatalyst (activity, stability, substrate/product inhibition), and (iii) process (catalyst preparation, reactor type, operation mode). This chapter focuses on these parameters as well as assessment of criteria to be considered for the application of enzymes in an industrial environment.
AB - Enzymes are typically the catalyst of choice when high atom efficiency and high selectivity are desired. However, the use of enzymes for organic synthesis represents a multiparameter challenge. Development of efficient enzymatic reactions necessitates careful evaluation of three parameters: (i) reaction of interest (solubility of substrates/products, reaction medium, thermodynamic equilibrium), (ii) biocatalyst (activity, stability, substrate/product inhibition), and (iii) process (catalyst preparation, reactor type, operation mode). This chapter focuses on these parameters as well as assessment of criteria to be considered for the application of enzymes in an industrial environment.
KW - Biocatalysis
KW - Bioprocess development
KW - Immobilization
KW - Multiphase reactions
KW - Reaction engineering
KW - Reactor types
KW - Rules of thumb in biocatalysis
UR - http://www.scopus.com/inward/record.url?scp=85090660582&partnerID=8YFLogxK
U2 - 10.1002/9783527813780.ch1_4
DO - 10.1002/9783527813780.ch1_4
M3 - Contribution to book/anthology
AN - SCOPUS:85090660582
SN - 9783527343850
SP - 71
EP - 94
BT - Industrial Enzyme Applications
PB - Wiley-VCH Verlag
ER -