Mathematical modeling and numerical simulation of arterial dissection based on a novel surgeon’s view

Research output: Contribution to journalArticleResearchpeer review

Authors

Research Organisations

External Research Organisations

  • Hannover Medical School (MHH)
View graph of relations

Details

Original languageEnglish
Pages (from-to)2097-2116
Number of pages20
JournalBiomechanics and Modeling in Mechanobiology
Volume22
Issue number6
Early online date8 Aug 2023
Publication statusPublished - Dec 2023

Abstract

This paper presents a mathematical model for arterial dissection based on a novel hypothesis proposed by a surgeon, Axel Haverich, see Haverich (Circulation 135(3):205–207, 2017. https://doi.org/10.1161/circulationaha.116.025407). In an attempt and based on clinical observations, he explained how three different arterial diseases, namely atherosclerosis, aneurysm and dissection have the same root in malfunctioning Vasa Vasorums (VVs) which are micro capillaries responsible for artery wall nourishment. The authors already proposed a mathematical framework for the modeling of atherosclerosis which is the thickening of the artery walls due to an inflammatory response to VVs dysfunction. A multiphysics model based on a phase-field approach coupled with mechanical deformation was proposed for this purpose. The kinematics of mechanical deformation was described using finite strain theory. The entire model is three-dimensional and fully based on a macroscopic continuum description. The objective here is to extend that model by incorporating a damage mechanism in order to capture the tearing (rupture) in the artery wall as a result of micro-injuries in VV. Unlike the existing damage-based model of the dissection in the literature, here the damage is driven by the internal bleeding (hematoma) rather than purely mechanical external loading. The numerical implementation is carried out using finite element method (FEM).

Keywords

    Atherosclerosis, Dissection, Finite element method, Phase-field modeling, Vasa vasorum

ASJC Scopus subject areas

Cite this

Mathematical modeling and numerical simulation of arterial dissection based on a novel surgeon’s view. / Soleimani, Meisam; Deo, Rohan; Hudobivnik, Blaz et al.

In: Biomechanics and Modeling in Mechanobiology, Vol. 22, No. 6, 12.2023, p. 2097-2116.

Research output: Contribution to journalArticleResearchpeer review

Soleimani M, Deo R, Hudobivnik B, Poyanmehr R, Haverich A, Wriggers P. Mathematical modeling and numerical simulation of arterial dissection based on a novel surgeon’s view. Biomechanics and Modeling in Mechanobiology. 2023 Dec;22(6):2097-2116. Epub 2023 Aug 8. doi: 10.1007/s10237-023-01753-y
Download
@article{dc5644294c0d4b31893b20b111dcfd71,
title = "Mathematical modeling and numerical simulation of arterial dissection based on a novel surgeon{\textquoteright}s view",
abstract = "This paper presents a mathematical model for arterial dissection based on a novel hypothesis proposed by a surgeon, Axel Haverich, see Haverich (Circulation 135(3):205–207, 2017. https://doi.org/10.1161/circulationaha.116.025407). In an attempt and based on clinical observations, he explained how three different arterial diseases, namely atherosclerosis, aneurysm and dissection have the same root in malfunctioning Vasa Vasorums (VVs) which are micro capillaries responsible for artery wall nourishment. The authors already proposed a mathematical framework for the modeling of atherosclerosis which is the thickening of the artery walls due to an inflammatory response to VVs dysfunction. A multiphysics model based on a phase-field approach coupled with mechanical deformation was proposed for this purpose. The kinematics of mechanical deformation was described using finite strain theory. The entire model is three-dimensional and fully based on a macroscopic continuum description. The objective here is to extend that model by incorporating a damage mechanism in order to capture the tearing (rupture) in the artery wall as a result of micro-injuries in VV. Unlike the existing damage-based model of the dissection in the literature, here the damage is driven by the internal bleeding (hematoma) rather than purely mechanical external loading. The numerical implementation is carried out using finite element method (FEM).",
keywords = "Atherosclerosis, Dissection, Finite element method, Phase-field modeling, Vasa vasorum",
author = "Meisam Soleimani and Rohan Deo and Blaz Hudobivnik and Reza Poyanmehr and Axel Haverich and Peter Wriggers",
year = "2023",
month = dec,
doi = "10.1007/s10237-023-01753-y",
language = "English",
volume = "22",
pages = "2097--2116",
journal = "Biomechanics and Modeling in Mechanobiology",
issn = "1617-7959",
publisher = "Springer Verlag",
number = "6",

}

Download

TY - JOUR

T1 - Mathematical modeling and numerical simulation of arterial dissection based on a novel surgeon’s view

AU - Soleimani, Meisam

AU - Deo, Rohan

AU - Hudobivnik, Blaz

AU - Poyanmehr, Reza

AU - Haverich, Axel

AU - Wriggers, Peter

PY - 2023/12

Y1 - 2023/12

N2 - This paper presents a mathematical model for arterial dissection based on a novel hypothesis proposed by a surgeon, Axel Haverich, see Haverich (Circulation 135(3):205–207, 2017. https://doi.org/10.1161/circulationaha.116.025407). In an attempt and based on clinical observations, he explained how three different arterial diseases, namely atherosclerosis, aneurysm and dissection have the same root in malfunctioning Vasa Vasorums (VVs) which are micro capillaries responsible for artery wall nourishment. The authors already proposed a mathematical framework for the modeling of atherosclerosis which is the thickening of the artery walls due to an inflammatory response to VVs dysfunction. A multiphysics model based on a phase-field approach coupled with mechanical deformation was proposed for this purpose. The kinematics of mechanical deformation was described using finite strain theory. The entire model is three-dimensional and fully based on a macroscopic continuum description. The objective here is to extend that model by incorporating a damage mechanism in order to capture the tearing (rupture) in the artery wall as a result of micro-injuries in VV. Unlike the existing damage-based model of the dissection in the literature, here the damage is driven by the internal bleeding (hematoma) rather than purely mechanical external loading. The numerical implementation is carried out using finite element method (FEM).

AB - This paper presents a mathematical model for arterial dissection based on a novel hypothesis proposed by a surgeon, Axel Haverich, see Haverich (Circulation 135(3):205–207, 2017. https://doi.org/10.1161/circulationaha.116.025407). In an attempt and based on clinical observations, he explained how three different arterial diseases, namely atherosclerosis, aneurysm and dissection have the same root in malfunctioning Vasa Vasorums (VVs) which are micro capillaries responsible for artery wall nourishment. The authors already proposed a mathematical framework for the modeling of atherosclerosis which is the thickening of the artery walls due to an inflammatory response to VVs dysfunction. A multiphysics model based on a phase-field approach coupled with mechanical deformation was proposed for this purpose. The kinematics of mechanical deformation was described using finite strain theory. The entire model is three-dimensional and fully based on a macroscopic continuum description. The objective here is to extend that model by incorporating a damage mechanism in order to capture the tearing (rupture) in the artery wall as a result of micro-injuries in VV. Unlike the existing damage-based model of the dissection in the literature, here the damage is driven by the internal bleeding (hematoma) rather than purely mechanical external loading. The numerical implementation is carried out using finite element method (FEM).

KW - Atherosclerosis

KW - Dissection

KW - Finite element method

KW - Phase-field modeling

KW - Vasa vasorum

UR - http://www.scopus.com/inward/record.url?scp=85167362095&partnerID=8YFLogxK

U2 - 10.1007/s10237-023-01753-y

DO - 10.1007/s10237-023-01753-y

M3 - Article

C2 - 37552344

AN - SCOPUS:85167362095

VL - 22

SP - 2097

EP - 2116

JO - Biomechanics and Modeling in Mechanobiology

JF - Biomechanics and Modeling in Mechanobiology

SN - 1617-7959

IS - 6

ER -

By the same author(s)