Details
| Original language | English |
|---|---|
| Pages (from-to) | 1859-1869 |
| Number of pages | 11 |
| Journal | JOM |
| Volume | 72 |
| Issue number | 5 |
| Publication status | Published - 25 Feb 2020 |
Abstract
If bone defects occur, the body’s own healing mechanism can close them below a critical size; for larger defects, bone autografts are used. These are typically cut from the same person’s hip in a second surgery. Consequently, the risk of complications, such as inflammations, rises. To avoid the risks resulting from the second surgery, absorbable, open-pored implants can be used. In the present study, the suitability of different magnesium alloys as absorbable porous bone substitute material has been investigated. Using the investment casting process with its design flexibility, the implant’s structure can be adapted to the ideal pore geometry with respect to bone ingrowth behavior. Different magnesium alloys (Mg-La2, LAE442, and ZX61) were studied and rated in terms of their degradation rate, bone ingrowth behavior, biocompatibility, and resorbability of the individual alloying elements.
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In: JOM, Vol. 72, No. 5, 25.02.2020, p. 1859-1869.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Magnesium Alloys for Open-Pored Bioresorbable Implants
AU - Maier, Hans Jürgen
AU - Julmi, Stefan
AU - Behrens, Sabine
AU - Klose, Christian
AU - Gartzke, Ann Kathrin
AU - Wriggers, Peter
AU - Waselau, Anja Christina
AU - Meyer-Lindenberg, Andrea
N1 - Funding information: Open Access funding provided by Projekt DEAL. Financial supported by the German Research Foundation (DFG) within the project “Interfacial effects and ingrowing behavior of magnesium-based foams as bioresorbable bone substitute material” (Grant No. 271761343) is gratefully acknowledged. The Xradia 520 Versa used in this study was also funded by the DFG (Grant No. 316923185).
PY - 2020/2/25
Y1 - 2020/2/25
N2 - If bone defects occur, the body’s own healing mechanism can close them below a critical size; for larger defects, bone autografts are used. These are typically cut from the same person’s hip in a second surgery. Consequently, the risk of complications, such as inflammations, rises. To avoid the risks resulting from the second surgery, absorbable, open-pored implants can be used. In the present study, the suitability of different magnesium alloys as absorbable porous bone substitute material has been investigated. Using the investment casting process with its design flexibility, the implant’s structure can be adapted to the ideal pore geometry with respect to bone ingrowth behavior. Different magnesium alloys (Mg-La2, LAE442, and ZX61) were studied and rated in terms of their degradation rate, bone ingrowth behavior, biocompatibility, and resorbability of the individual alloying elements.
AB - If bone defects occur, the body’s own healing mechanism can close them below a critical size; for larger defects, bone autografts are used. These are typically cut from the same person’s hip in a second surgery. Consequently, the risk of complications, such as inflammations, rises. To avoid the risks resulting from the second surgery, absorbable, open-pored implants can be used. In the present study, the suitability of different magnesium alloys as absorbable porous bone substitute material has been investigated. Using the investment casting process with its design flexibility, the implant’s structure can be adapted to the ideal pore geometry with respect to bone ingrowth behavior. Different magnesium alloys (Mg-La2, LAE442, and ZX61) were studied and rated in terms of their degradation rate, bone ingrowth behavior, biocompatibility, and resorbability of the individual alloying elements.
UR - http://www.scopus.com/inward/record.url?scp=85080071244&partnerID=8YFLogxK
U2 - 10.1007/s11837-020-04078-8
DO - 10.1007/s11837-020-04078-8
M3 - Article
AN - SCOPUS:85080071244
VL - 72
SP - 1859
EP - 1869
JO - JOM
JF - JOM
SN - 1047-4838
IS - 5
ER -