Details
| Original language | English |
|---|---|
| Pages (from-to) | 723-737 |
| Number of pages | 15 |
| Journal | Natural Product Reports |
| Volume | 32 |
| Issue number | 5 |
| Publication status | Published - 1 May 2015 |
Abstract
Covering: 1981 to 2015 This conceptual review examines the ideal multistep synthesis from the perspective of nature. We suggest that besides step- and redox economies, one other key to efficiency is steady state processing with intermediates that are immediately transformed to the next intermediate when formed. We discuss four of nature's strategies (multicatalysis, domino reactions, iteration and compartmentation) that commonly proceed via short-lived intermediates and show that these strategies are also part of the chemist's portfolio. We particularly focus on compartmentation which in nature is found microscopically within cells (organelles) and between cells and on a molecular level on multiprotein scaffolds (e.g. in polyketide synthases) and demonstrate how compartmentation is manifested in modern multistep flow synthesis. This journal is
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural Product Reports, Vol. 32, No. 5, 01.05.2015, p. 723-737.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Lessons from the Synthetic Chemist Nature
AU - Jürjens, Gerrit
AU - Kirschning, Andreas
AU - Candito, David A.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Covering: 1981 to 2015 This conceptual review examines the ideal multistep synthesis from the perspective of nature. We suggest that besides step- and redox economies, one other key to efficiency is steady state processing with intermediates that are immediately transformed to the next intermediate when formed. We discuss four of nature's strategies (multicatalysis, domino reactions, iteration and compartmentation) that commonly proceed via short-lived intermediates and show that these strategies are also part of the chemist's portfolio. We particularly focus on compartmentation which in nature is found microscopically within cells (organelles) and between cells and on a molecular level on multiprotein scaffolds (e.g. in polyketide synthases) and demonstrate how compartmentation is manifested in modern multistep flow synthesis. This journal is
AB - Covering: 1981 to 2015 This conceptual review examines the ideal multistep synthesis from the perspective of nature. We suggest that besides step- and redox economies, one other key to efficiency is steady state processing with intermediates that are immediately transformed to the next intermediate when formed. We discuss four of nature's strategies (multicatalysis, domino reactions, iteration and compartmentation) that commonly proceed via short-lived intermediates and show that these strategies are also part of the chemist's portfolio. We particularly focus on compartmentation which in nature is found microscopically within cells (organelles) and between cells and on a molecular level on multiprotein scaffolds (e.g. in polyketide synthases) and demonstrate how compartmentation is manifested in modern multistep flow synthesis. This journal is
UR - http://www.scopus.com/inward/record.url?scp=84928894579&partnerID=8YFLogxK
U2 - 10.1039/c4np00160e
DO - 10.1039/c4np00160e
M3 - Review article
C2 - 25728458
AN - SCOPUS:84928894579
VL - 32
SP - 723
EP - 737
JO - Natural Product Reports
JF - Natural Product Reports
SN - 0265-0568
IS - 5
ER -