Details
| Original language | English |
|---|---|
| Title of host publication | Cellular Signal Transduction in Toxicology and Pharmacology |
| Subtitle of host publication | Data Collection, Analysis, and Interpretation |
| Editors | Jonathan W. Boyd, Richard R. Neubig |
| Publisher | Wiley-Blackwell |
| Pages | 1-19 |
| Number of pages | 19 |
| ISBN (Electronic) | 9781119060208 |
| ISBN (Print) | 9781119060260 |
| Publication status | Published - 22 Mar 2019 |
Abstract
Understanding the potential biological ramifications associated with altered cellular signal transduction processes is essential for research, development, testing, and evaluation of new chemical compounds for both pharmacology and toxicology. Beyond sensory perception systems that are highly innervated with direct linkages to the central nervous system, all biological interactions with the exogenous world necessitate a cellular understanding of signal transduction. This involves both extracellular and intracellular trafficking of information, which requires dynamic interplay between the plasma membrane, organelles, and cellular constituents in order to optimize the response to a changing environment. While every cellular constituent plays a role within signal transduction, some organelles are critical for both the creation and maintenance of signaling capabilities, including the mitochondria, endoplasmic reticulum, and the nucleus. Beyond their well-known functional responsibilities, these organelles also serve to integrate many disparate signals that originate from both the extracellular matrix and the cytoplasm.
Keywords
- Cellular signal transduction, Endoplasmic reticulum, Mitochondria, Nucleus, Plasma membrane, Sensory perception
ASJC Scopus subject areas
Cite this
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Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation. ed. / Jonathan W. Boyd; Richard R. Neubig. Wiley-Blackwell, 2019. p. 1-19.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Introduction to cellular signal transduction
T2 - The connection between a biological system and its surroundings
AU - Boyd, Jonathan W.
AU - Neubig, Richard R.
AU - Han, Alice
AU - Prediger, Maren
PY - 2019/3/22
Y1 - 2019/3/22
N2 - Understanding the potential biological ramifications associated with altered cellular signal transduction processes is essential for research, development, testing, and evaluation of new chemical compounds for both pharmacology and toxicology. Beyond sensory perception systems that are highly innervated with direct linkages to the central nervous system, all biological interactions with the exogenous world necessitate a cellular understanding of signal transduction. This involves both extracellular and intracellular trafficking of information, which requires dynamic interplay between the plasma membrane, organelles, and cellular constituents in order to optimize the response to a changing environment. While every cellular constituent plays a role within signal transduction, some organelles are critical for both the creation and maintenance of signaling capabilities, including the mitochondria, endoplasmic reticulum, and the nucleus. Beyond their well-known functional responsibilities, these organelles also serve to integrate many disparate signals that originate from both the extracellular matrix and the cytoplasm.
AB - Understanding the potential biological ramifications associated with altered cellular signal transduction processes is essential for research, development, testing, and evaluation of new chemical compounds for both pharmacology and toxicology. Beyond sensory perception systems that are highly innervated with direct linkages to the central nervous system, all biological interactions with the exogenous world necessitate a cellular understanding of signal transduction. This involves both extracellular and intracellular trafficking of information, which requires dynamic interplay between the plasma membrane, organelles, and cellular constituents in order to optimize the response to a changing environment. While every cellular constituent plays a role within signal transduction, some organelles are critical for both the creation and maintenance of signaling capabilities, including the mitochondria, endoplasmic reticulum, and the nucleus. Beyond their well-known functional responsibilities, these organelles also serve to integrate many disparate signals that originate from both the extracellular matrix and the cytoplasm.
KW - Cellular signal transduction
KW - Endoplasmic reticulum
KW - Mitochondria
KW - Nucleus
KW - Plasma membrane
KW - Sensory perception
UR - http://www.scopus.com/inward/record.url?scp=85132688135&partnerID=8YFLogxK
U2 - 10.1002/9781119060208.ch1
DO - 10.1002/9781119060208.ch1
M3 - Contribution to book/anthology
AN - SCOPUS:85132688135
SN - 9781119060260
SP - 1
EP - 19
BT - Cellular Signal Transduction in Toxicology and Pharmacology
A2 - Boyd, Jonathan W.
A2 - Neubig, Richard R.
PB - Wiley-Blackwell
ER -