Details
| Original language | English |
|---|---|
| Title of host publication | Translational Biophotonics |
| Subtitle of host publication | Diagnostics and Therapeutics III |
| Editors | Zhiwei Huang, Lothar D. Lilge |
| Publisher | SPIE |
| ISBN (electronic) | 9781510664630 |
| Publication status | Published - 11 Aug 2023 |
| Event | European Conferences on Biomedical Optics 2023 - Munich, Germany Duration: 25 Jun 2023 → 29 Jun 2023 |
Publication series
| Name | Proceedings of SPIE - The International Society for Optical Engineering |
|---|---|
| Volume | 12627 |
| ISSN (Print) | 0277-786X |
| ISSN (electronic) | 1996-756X |
Abstract
Cutaneous melanoma is one of the most lethal types of skin cancer. Non-invasively distinguishing malignant melanoma from benign tumours has always been a challenge. In this paper, an OCT and co-localized Raman spectroscopic system was built and Raman spectroscopy was used to measure skin samples of suspected melanoma lesions and their surrounding healthy areas non-invasively and in vivo. The Raman spectral signal intensities of the lesions increased at 1320 cm-1 and 1650 cm-1, while the content of carotenoids decreased, compared to that of the healthy skin samples. The results of the Shapley analysis values showed that the spectral peaks at 1320 cm-1 and 1650 cm-1 had a more significant effect on the differentiation of lesions from normal skin. This result can be used to guide the diagnosis of melanoma based on Raman spectroscopy.
Keywords
- in vivo skins, melanoma diagnosis, Raman spectroscopy, Shapley values
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Condensed Matter Physics
- Computer Science(all)
- Computer Science Applications
- Mathematics(all)
- Applied Mathematics
- Engineering(all)
- Electrical and Electronic Engineering
Sustainable Development Goals
Cite this
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- BibTeX
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Translational Biophotonics: Diagnostics and Therapeutics III. ed. / Zhiwei Huang; Lothar D. Lilge. SPIE, 2023. 1262704 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 12627).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - In vivo Raman Spectroscopic Study of Suspected Melanoma Skin Lesions and Healthy Skin
AU - Wu, Di
AU - Kukk, Anatoly Fedorov
AU - Emmert, Steffen
AU - Roth, Bernhard
N1 - Funding information: The authors acknowledge financial support from the German Research Foundation DFG (German Research Foundation, Project ID RO 3471/18-1 and EM 63/13-1). Also, financial support from the German Research Foundation (DFG) under Germany’s Excellence Strategy within the Cluster of Excellence PhoenixD (EXC 2122, Project ID 390833453) is acknowledged.
PY - 2023/8/11
Y1 - 2023/8/11
N2 - Cutaneous melanoma is one of the most lethal types of skin cancer. Non-invasively distinguishing malignant melanoma from benign tumours has always been a challenge. In this paper, an OCT and co-localized Raman spectroscopic system was built and Raman spectroscopy was used to measure skin samples of suspected melanoma lesions and their surrounding healthy areas non-invasively and in vivo. The Raman spectral signal intensities of the lesions increased at 1320 cm-1 and 1650 cm-1, while the content of carotenoids decreased, compared to that of the healthy skin samples. The results of the Shapley analysis values showed that the spectral peaks at 1320 cm-1 and 1650 cm-1 had a more significant effect on the differentiation of lesions from normal skin. This result can be used to guide the diagnosis of melanoma based on Raman spectroscopy.
AB - Cutaneous melanoma is one of the most lethal types of skin cancer. Non-invasively distinguishing malignant melanoma from benign tumours has always been a challenge. In this paper, an OCT and co-localized Raman spectroscopic system was built and Raman spectroscopy was used to measure skin samples of suspected melanoma lesions and their surrounding healthy areas non-invasively and in vivo. The Raman spectral signal intensities of the lesions increased at 1320 cm-1 and 1650 cm-1, while the content of carotenoids decreased, compared to that of the healthy skin samples. The results of the Shapley analysis values showed that the spectral peaks at 1320 cm-1 and 1650 cm-1 had a more significant effect on the differentiation of lesions from normal skin. This result can be used to guide the diagnosis of melanoma based on Raman spectroscopy.
KW - in vivo skins
KW - melanoma diagnosis
KW - Raman spectroscopy
KW - Shapley values
UR - http://www.scopus.com/inward/record.url?scp=85172196828&partnerID=8YFLogxK
U2 - 10.1117/12.2670621
DO - 10.1117/12.2670621
M3 - Conference contribution
AN - SCOPUS:85172196828
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Translational Biophotonics
A2 - Huang, Zhiwei
A2 - Lilge, Lothar D.
PB - SPIE
T2 - European Conferences on Biomedical Optics 2023
Y2 - 25 June 2023 through 29 June 2023
ER -