Details
| Original language | English |
|---|---|
| Pages (from-to) | 734-740 |
| Number of pages | 7 |
| Journal | ASAIO journal |
| Volume | 70 |
| Issue number | 9 |
| Publication status | Published - Sept 2024 |
Abstract
Severe right heart failure, often overlooked and challenging to manage, has prompted a growing interest in innovative approaches to provide functional support. This study uses experimentation in large porcine models to introduce a novel prototype of a pulsatile mechanical circulatory support device and document its effects when deployed as a right ventricular assist device (RVAD). The pulsatile ventricular assist platform (pVAP), featuring a membrane pump driven by an intra-aortic balloon pump console, actively generates pulsatile flow to propel right ventricular blood into the pulmonary artery. This novel prototype demonstrates promising potential in addressing the challenges of right heart failure management. After preliminary in vitro assessments, the pVAP was tested on seven porcine models in a healthy state and after the induction of right ventricular failure. During the procedure, a set of standard (ie, standard-of-care) hemodynamic measurements was obtained. Additionally, invasive pressure-volume loop analysis was employed to examine left ventricular hemodynamics. Results indicated that activation of the pVAP during right ventricular failure significantly improved systemic hemodynamics and enhanced left ventricular function. This study sheds light on the potential of the pVAP in managing right heart failure.
Keywords
- paracorporal pulsatile pump, percutaneous RVAD, right heart failure, right ventricular assist device
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biophysics
- Chemical Engineering(all)
- Bioengineering
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
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In: ASAIO journal, Vol. 70, No. 9, 09.2024, p. 734-740.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Hemodynamical Evaluation of a New Surgically Implanted Pulsatile Right Ventricular Assist Device Driven by a Conventional Intra-Aortic Balloon Pump Console
AU - Knigge, Sara
AU - Dogan, Günes
AU - Deniz, Ezin
AU - Ismail, Youseph
AU - Optenhöfel, Jörg
AU - Schana, Liam
AU - Merzah, Ali S.
AU - Hanke, Jasmin S.
AU - Ismail, Issam
AU - Malchin, Oren
AU - Bastos, Marcelo
AU - Popov, Aron F.
AU - Weymann, Alexander
AU - Ruhparwar, Arjang
AU - Schmack, Bastian
AU - Schmitto, Jan D.
N1 - Publisher Copyright: Copyright © ASAIO 2024.
PY - 2024/9
Y1 - 2024/9
N2 - Severe right heart failure, often overlooked and challenging to manage, has prompted a growing interest in innovative approaches to provide functional support. This study uses experimentation in large porcine models to introduce a novel prototype of a pulsatile mechanical circulatory support device and document its effects when deployed as a right ventricular assist device (RVAD). The pulsatile ventricular assist platform (pVAP), featuring a membrane pump driven by an intra-aortic balloon pump console, actively generates pulsatile flow to propel right ventricular blood into the pulmonary artery. This novel prototype demonstrates promising potential in addressing the challenges of right heart failure management. After preliminary in vitro assessments, the pVAP was tested on seven porcine models in a healthy state and after the induction of right ventricular failure. During the procedure, a set of standard (ie, standard-of-care) hemodynamic measurements was obtained. Additionally, invasive pressure-volume loop analysis was employed to examine left ventricular hemodynamics. Results indicated that activation of the pVAP during right ventricular failure significantly improved systemic hemodynamics and enhanced left ventricular function. This study sheds light on the potential of the pVAP in managing right heart failure.
AB - Severe right heart failure, often overlooked and challenging to manage, has prompted a growing interest in innovative approaches to provide functional support. This study uses experimentation in large porcine models to introduce a novel prototype of a pulsatile mechanical circulatory support device and document its effects when deployed as a right ventricular assist device (RVAD). The pulsatile ventricular assist platform (pVAP), featuring a membrane pump driven by an intra-aortic balloon pump console, actively generates pulsatile flow to propel right ventricular blood into the pulmonary artery. This novel prototype demonstrates promising potential in addressing the challenges of right heart failure management. After preliminary in vitro assessments, the pVAP was tested on seven porcine models in a healthy state and after the induction of right ventricular failure. During the procedure, a set of standard (ie, standard-of-care) hemodynamic measurements was obtained. Additionally, invasive pressure-volume loop analysis was employed to examine left ventricular hemodynamics. Results indicated that activation of the pVAP during right ventricular failure significantly improved systemic hemodynamics and enhanced left ventricular function. This study sheds light on the potential of the pVAP in managing right heart failure.
KW - paracorporal pulsatile pump
KW - percutaneous RVAD
KW - right heart failure
KW - right ventricular assist device
UR - http://www.scopus.com/inward/record.url?scp=85199344734&partnerID=8YFLogxK
U2 - 10.1097/MAT.0000000000002197
DO - 10.1097/MAT.0000000000002197
M3 - Article
C2 - 38569184
AN - SCOPUS:85199344734
VL - 70
SP - 734
EP - 740
JO - ASAIO journal
JF - ASAIO journal
SN - 1058-2916
IS - 9
ER -