Details
Original language | English |
---|---|
Article number | 107781 |
Number of pages | 15 |
Journal | Computers and Structures |
Volume | 315 |
Early online date | 24 Apr 2025 |
Publication status | E-pub ahead of print - 24 Apr 2025 |
Abstract
Many soft biological structures have natural features of viscoelastic and hyperelastic materials. Research focused on the growth biomechanics of these structures is challenging from theoretical and experimental points of view, especially when irregular forms/defects of biological objects should be considered. To this aim, an effort is made in this paper to develop a general nonlinear finite element model for the growth of biological soft structures such as arteries, skin or different tissues. The non-Newtonian fluid is considered for viscoelastic branches. The effect of variation in thickness growth and irregular geometry as well as defects of biostructure is taken into account for the first time. The general nonlinear formulations are obtained for isotropic as well as anisotropic material properties. Furthermore, to resolve evolution equations resulting of internal variables for growth as well as viscoelastic branches, two effective implicit trapezoidal time integration schemes are employed. To study the applicability of the proposed model, the obtained results are compared with results from clinical studies for skin growth, available in the literature. The results demonstrate that the present model enables to capture of the experimental observations with very good accuracy. Additionally, the presented model enables to study of different shapes of biostructure, and variation in thickness growth, including regular and irregular defects, which have never been investigated previously.
Keywords
- Computational modeling, Growth biomechanics, Irregular defects, Nonlinear FE model, Soft tissues
ASJC Scopus subject areas
- Engineering(all)
- Civil and Structural Engineering
- Mathematics(all)
- Modelling and Simulation
- Materials Science(all)
- General Materials Science
- Engineering(all)
- Mechanical Engineering
- Computer Science(all)
- Computer Science Applications
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In: Computers and Structures, Vol. 315, 107781, 08.2025.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Generalized reconfigurations and growth mechanics of biological structures considering regular and irregular features
T2 - A computational study
AU - Firouzi, Nasser
AU - Kamil Żur, Krzysztof
AU - Rabczuk, Timon
AU - Zhuang, Xiaoying
N1 - Publisher Copyright: © 2025 The Author(s)
PY - 2025/4/24
Y1 - 2025/4/24
N2 - Many soft biological structures have natural features of viscoelastic and hyperelastic materials. Research focused on the growth biomechanics of these structures is challenging from theoretical and experimental points of view, especially when irregular forms/defects of biological objects should be considered. To this aim, an effort is made in this paper to develop a general nonlinear finite element model for the growth of biological soft structures such as arteries, skin or different tissues. The non-Newtonian fluid is considered for viscoelastic branches. The effect of variation in thickness growth and irregular geometry as well as defects of biostructure is taken into account for the first time. The general nonlinear formulations are obtained for isotropic as well as anisotropic material properties. Furthermore, to resolve evolution equations resulting of internal variables for growth as well as viscoelastic branches, two effective implicit trapezoidal time integration schemes are employed. To study the applicability of the proposed model, the obtained results are compared with results from clinical studies for skin growth, available in the literature. The results demonstrate that the present model enables to capture of the experimental observations with very good accuracy. Additionally, the presented model enables to study of different shapes of biostructure, and variation in thickness growth, including regular and irregular defects, which have never been investigated previously.
AB - Many soft biological structures have natural features of viscoelastic and hyperelastic materials. Research focused on the growth biomechanics of these structures is challenging from theoretical and experimental points of view, especially when irregular forms/defects of biological objects should be considered. To this aim, an effort is made in this paper to develop a general nonlinear finite element model for the growth of biological soft structures such as arteries, skin or different tissues. The non-Newtonian fluid is considered for viscoelastic branches. The effect of variation in thickness growth and irregular geometry as well as defects of biostructure is taken into account for the first time. The general nonlinear formulations are obtained for isotropic as well as anisotropic material properties. Furthermore, to resolve evolution equations resulting of internal variables for growth as well as viscoelastic branches, two effective implicit trapezoidal time integration schemes are employed. To study the applicability of the proposed model, the obtained results are compared with results from clinical studies for skin growth, available in the literature. The results demonstrate that the present model enables to capture of the experimental observations with very good accuracy. Additionally, the presented model enables to study of different shapes of biostructure, and variation in thickness growth, including regular and irregular defects, which have never been investigated previously.
KW - Computational modeling
KW - Growth biomechanics
KW - Irregular defects
KW - Nonlinear FE model
KW - Soft tissues
UR - http://www.scopus.com/inward/record.url?scp=105003172329&partnerID=8YFLogxK
U2 - 10.1016/j.compstruc.2025.107781
DO - 10.1016/j.compstruc.2025.107781
M3 - Article
AN - SCOPUS:105003172329
VL - 315
JO - Computers and Structures
JF - Computers and Structures
SN - 0045-7949
M1 - 107781
ER -