Details
| Original language | English |
|---|---|
| Article number | 44 |
| Journal | Frontiers in Molecular Biosciences |
| Volume | 4 |
| Issue number | JUL |
| Publication status | Published - 12 Jul 2017 |
Abstract
Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics.
Keywords
- AAA+ protease complexes, Adaptor proteins, Bacillus subtilis, Chaperones, Hsp100/Clp proteins, McsB, Protein quality control, Regulatory proteolysis, AAA plus protease complexes, adaptor proteins, protein quality control, regulatory proteolysis, chaperones
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
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In: Frontiers in Molecular Biosciences, Vol. 4, No. JUL, 44, 12.07.2017.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Functional diversity of AAA+ protease complexes in Bacillus subtilis
AU - Elsholz, Alexander K.W.
AU - Birk, Marlene S.
AU - Charpentier, Emmanuelle
AU - Turgay, Kürsad
N1 - Funding information: Work in the Laboratory of KT was supported by the Deutsche Forschungsgemeinschaft. Work in the Laboratory of EC was supported by the Göran Gustafsson Foundation (Göran Gustafsson Prize), Umeå University, the Max Planck Foundation and the Max Planck Society. The authors want to thank Christina Gross for critical reading and many helpful comments on the manuscript.
PY - 2017/7/12
Y1 - 2017/7/12
N2 - Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics.
AB - Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics.
KW - AAA+ protease complexes
KW - Adaptor proteins
KW - Bacillus subtilis
KW - Chaperones
KW - Hsp100/Clp proteins
KW - McsB
KW - Protein quality control
KW - Regulatory proteolysis
KW - AAA plus protease complexes
KW - adaptor proteins
KW - protein quality control
KW - regulatory proteolysis
KW - chaperones
UR - http://www.scopus.com/inward/record.url?scp=85039775261&partnerID=8YFLogxK
U2 - 10.3389/fmolb.2017.00044
DO - 10.3389/fmolb.2017.00044
M3 - Review article
AN - SCOPUS:85039775261
VL - 4
JO - Frontiers in Molecular Biosciences
JF - Frontiers in Molecular Biosciences
IS - JUL
M1 - 44
ER -