Details
| Original language | English |
|---|---|
| Article number | 107680 |
| Journal | INTERMETALLICS |
| Volume | 149 |
| Early online date | 8 Aug 2022 |
| Publication status | Published - Oct 2022 |
Abstract
This paper presents a thorough biocompatibility evaluation of a CoCrMo medium entropy alloy to assess its potential to be utilized in orthopedic and dental implants. For this purpose, a wide range of systematic experiments were carried out, including static immersion, cell culture and radiation experiments. In particular, chemical biocompatibility and ion release behavior of the CoCrMo alloy were studied by carrying out static immersion experiments in artificial saliva (AS), simulated body fluid (SBF) and fetal bovine serum (FBS). Detailed analysis of the surfaces of the tested samples demonstrated that both passive oxide layer and hydroxyapatite formation occur on the CoCrMo sample surfaces immersed in AS, SBF and FBS for 28 days. The response of living cells to the CoCrMo alloy was tested utilizing cell culture experiments, and the evidence of Saos-2 cell viability and proliferation supported the static biocompatibility experiment results, indicating the potential of the CoCrMo alloy to be utilized as an orthopedic implant material. Finally, the effect of a CoCrMo implant on the actual radiation dose induced upon malignant tissue in the vicinity of the implant during a radiotherapy was evaluated by applying medical grade radiation to water phantoms circumventing CoCrMo samples. The results showed that the radiation accumulation in the tissue within the immediate vicinity of a CoCrMo implant would be a minimum, eliminating some of the undesired side effects. Overall, the results of the three different types of experiments reported in this paper have clearly demonstrated that the CoCrMo medium entropy alloy investigated in this study has significant potential to be utilized as a safe implant material in dental and orthopedic implants.
Keywords
- Biocompatibility, CoCrMo, Corrosion, Dental implant, Irradiation, Orthopedic implant
ASJC Scopus subject areas
- Chemistry(all)
- Engineering(all)
- Mechanics of Materials
- Engineering(all)
- Mechanical Engineering
- Materials Science(all)
- Metals and Alloys
- Materials Science(all)
- Materials Chemistry
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: INTERMETALLICS, Vol. 149, 107680, 10.2022.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - From corrosion behavior to radiation response
T2 - A comprehensive biocompatibility assessment of a CoCrMo medium entropy alloy for utility in orthopedic and dental implants
AU - Gurel, S.
AU - Nazarahari, A.
AU - Canadinc, D.
AU - Gerstein, G.
AU - Maier, H. J.
AU - Cabuk, H.
AU - Bukulmez, T.
AU - Cananoglu, M.
AU - Yagci, M. B.
AU - Toker, S. M.
AU - Gunes, S.
AU - Soykan, M. N.
N1 - Funding Information: Overall, the thorough surface analysis presented herein proved that both passive oxide layer and hydroxyapatite formation occur on the CoCrMo sample surfaces immersed in AS, SBF and FBS for 28 days. While the highest rate of Ca and P formation on CoCrMo surface is prevalent in the FBS solution, the least amount of Ca and P formation is observed when the samples are immersed in SBF (Fig. 7). On the other hand, Cr-like passivity is supported more by SBF and AS solutions than by the FBS.This study was supported by the BAGEP Award of the Science Academy. The authors also acknowledge the financial support by the Koç University Graduate School of Sciences and Engineering. The German part of the study was supported by Deutsche Forschungsgemeinschaft (project number 426335750). S.M. Toker acknowledges the support by Eskisehir Osmangazi University BAP research funds (Grant 2018/15038).
PY - 2022/10
Y1 - 2022/10
N2 - This paper presents a thorough biocompatibility evaluation of a CoCrMo medium entropy alloy to assess its potential to be utilized in orthopedic and dental implants. For this purpose, a wide range of systematic experiments were carried out, including static immersion, cell culture and radiation experiments. In particular, chemical biocompatibility and ion release behavior of the CoCrMo alloy were studied by carrying out static immersion experiments in artificial saliva (AS), simulated body fluid (SBF) and fetal bovine serum (FBS). Detailed analysis of the surfaces of the tested samples demonstrated that both passive oxide layer and hydroxyapatite formation occur on the CoCrMo sample surfaces immersed in AS, SBF and FBS for 28 days. The response of living cells to the CoCrMo alloy was tested utilizing cell culture experiments, and the evidence of Saos-2 cell viability and proliferation supported the static biocompatibility experiment results, indicating the potential of the CoCrMo alloy to be utilized as an orthopedic implant material. Finally, the effect of a CoCrMo implant on the actual radiation dose induced upon malignant tissue in the vicinity of the implant during a radiotherapy was evaluated by applying medical grade radiation to water phantoms circumventing CoCrMo samples. The results showed that the radiation accumulation in the tissue within the immediate vicinity of a CoCrMo implant would be a minimum, eliminating some of the undesired side effects. Overall, the results of the three different types of experiments reported in this paper have clearly demonstrated that the CoCrMo medium entropy alloy investigated in this study has significant potential to be utilized as a safe implant material in dental and orthopedic implants.
AB - This paper presents a thorough biocompatibility evaluation of a CoCrMo medium entropy alloy to assess its potential to be utilized in orthopedic and dental implants. For this purpose, a wide range of systematic experiments were carried out, including static immersion, cell culture and radiation experiments. In particular, chemical biocompatibility and ion release behavior of the CoCrMo alloy were studied by carrying out static immersion experiments in artificial saliva (AS), simulated body fluid (SBF) and fetal bovine serum (FBS). Detailed analysis of the surfaces of the tested samples demonstrated that both passive oxide layer and hydroxyapatite formation occur on the CoCrMo sample surfaces immersed in AS, SBF and FBS for 28 days. The response of living cells to the CoCrMo alloy was tested utilizing cell culture experiments, and the evidence of Saos-2 cell viability and proliferation supported the static biocompatibility experiment results, indicating the potential of the CoCrMo alloy to be utilized as an orthopedic implant material. Finally, the effect of a CoCrMo implant on the actual radiation dose induced upon malignant tissue in the vicinity of the implant during a radiotherapy was evaluated by applying medical grade radiation to water phantoms circumventing CoCrMo samples. The results showed that the radiation accumulation in the tissue within the immediate vicinity of a CoCrMo implant would be a minimum, eliminating some of the undesired side effects. Overall, the results of the three different types of experiments reported in this paper have clearly demonstrated that the CoCrMo medium entropy alloy investigated in this study has significant potential to be utilized as a safe implant material in dental and orthopedic implants.
KW - Biocompatibility
KW - CoCrMo
KW - Corrosion
KW - Dental implant
KW - Irradiation
KW - Orthopedic implant
UR - http://www.scopus.com/inward/record.url?scp=85135692388&partnerID=8YFLogxK
U2 - 10.1016/j.intermet.2022.107680
DO - 10.1016/j.intermet.2022.107680
M3 - Article
AN - SCOPUS:85135692388
VL - 149
JO - INTERMETALLICS
JF - INTERMETALLICS
SN - 0966-9795
M1 - 107680
ER -