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Formation of Neural Networks in 3D Scaffolds Fabricated by Means of Laser Microstereolithography

Research output: Contribution to journal › Article › Research › peer review

Authors

  • M. V. Vedunova
  • P. S. Timashev
  • T. A. Mishchenko
  • E. V. Mitroshina
  • A. V. Koroleva
  • B. N. Chichkov

External Research Organisations

  • Lomonosov Moscow State University
  • Russian Ministry of Health
  • Russian Academy of Sciences (RAS)

Details

Original languageEnglish
Pages (from-to)616-621
Number of pages6
JournalBulletin of Experimental Biology and Medicine
Volume161
Issue number4
Publication statusPublished - 5 Sept 2015
Externally publishedYes

Abstract

We developed and tested new 3D scaffolds for neurotransplantation. Scaffolds of predetermined architectonic were prepared using microstereolithography technique. Scaffolds were highly biocompatible with the nervous tissue cells. In vitro studies showed that the material of fabricated scaffolds is not toxic for dissociated brain cells and promotes the formation of functional neural networks in the matrix. These results demonstrate the possibility of fabrication of tissue-engineering constructs for neurotransplantation based on created scaffolds.

Keywords

    3D polymeric scaffolds, Calcium imaging, Dissociated hippocampal cultures, Microstereolithography, Two-photon polymerization

ASJC Scopus subject areas

Cite this

Formation of Neural Networks in 3D Scaffolds Fabricated by Means of Laser Microstereolithography. / Vedunova, M. V.; Timashev, P. S.; Mishchenko, T. A. et al.
In: Bulletin of Experimental Biology and Medicine, Vol. 161, No. 4, 05.09.2015, p. 616-621.

Research output: Contribution to journal › Article › Research › peer review

Vedunova, MV, Timashev, PS, Mishchenko, TA, Mitroshina, EV, Koroleva, AV, Chichkov, BN, Panchenko, VY, Bagratashvili, VN & Mukhina, IV 2015, 'Formation of Neural Networks in 3D Scaffolds Fabricated by Means of Laser Microstereolithography', Bulletin of Experimental Biology and Medicine, vol. 161, no. 4, pp. 616-621. https://doi.org/10.1007/s10517-016-3470-7
Vedunova, M. V., Timashev, P. S., Mishchenko, T. A., Mitroshina, E. V., Koroleva, A. V., Chichkov, B. N., Panchenko, V. Y., Bagratashvili, V. N., & Mukhina, I. V. (2015). Formation of Neural Networks in 3D Scaffolds Fabricated by Means of Laser Microstereolithography. Bulletin of Experimental Biology and Medicine, 161(4), 616-621. https://doi.org/10.1007/s10517-016-3470-7
Vedunova MV, Timashev PS, Mishchenko TA, Mitroshina EV, Koroleva AV, Chichkov BN et al. Formation of Neural Networks in 3D Scaffolds Fabricated by Means of Laser Microstereolithography. Bulletin of Experimental Biology and Medicine. 2015 Sept 5;161(4):616-621. doi: 10.1007/s10517-016-3470-7
Vedunova, M. V. ; Timashev, P. S. ; Mishchenko, T. A. et al. / Formation of Neural Networks in 3D Scaffolds Fabricated by Means of Laser Microstereolithography. In: Bulletin of Experimental Biology and Medicine. 2015 ; Vol. 161, No. 4. pp. 616-621.
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