Flux-corrected transport stabilization of an evolutionary cross-diffusion cancer invasion model

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Original languageEnglish
Article number112711
JournalJournal of computational physics
Volume499
Early online date14 Dec 2023
Publication statusPublished - 15 Feb 2024

Abstract

In the present work, we investigate a model of the invasion of healthy tissue by cancer cells which is described by a system of nonlinear PDEs consisting of a cross-diffusion-reaction equation and two additional nonlinear ordinary differential equations. We show that when the convective part of the system, the haptotaxis term, is dominant, then straightforward numerical methods for the studied system may be unstable. We present an implicit finite element method using conforming P1 or Q1 finite elements to discretize the model in space and the θ-method for discretization in time. The discrete problem is stabilized using a nonlinear flux-corrected transport approach. It is proved that both the nonlinear scheme and the linearized problems used in fixed-point iterations are solvable and positivity preserving. Several numerical experiments are presented in 2D to demonstrate the performance of the proposed method.

Keywords

    Cancer invasion, Cross-diffusion equation, Existence of solutions, FEM-FCT stabilization, Positivity preservation

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Sustainable Development Goals

Cite this

Flux-corrected transport stabilization of an evolutionary cross-diffusion cancer invasion model. / Heydari, Shahin; Knobloch, Petr; Wick, Thomas.
In: Journal of computational physics, Vol. 499, 112711, 15.02.2024.

Research output: Contribution to journalArticleResearchpeer review

Heydari S, Knobloch P, Wick T. Flux-corrected transport stabilization of an evolutionary cross-diffusion cancer invasion model. Journal of computational physics. 2024 Feb 15;499:112711. Epub 2023 Dec 14. doi: 10.48550/arXiv.2307.08096, 10.1016/j.jcp.2023.112711
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abstract = "In the present work, we investigate a model of the invasion of healthy tissue by cancer cells which is described by a system of nonlinear PDEs consisting of a cross-diffusion-reaction equation and two additional nonlinear ordinary differential equations. We show that when the convective part of the system, the haptotaxis term, is dominant, then straightforward numerical methods for the studied system may be unstable. We present an implicit finite element method using conforming P1 or Q1 finite elements to discretize the model in space and the θ-method for discretization in time. The discrete problem is stabilized using a nonlinear flux-corrected transport approach. It is proved that both the nonlinear scheme and the linearized problems used in fixed-point iterations are solvable and positivity preserving. Several numerical experiments are presented in 2D to demonstrate the performance of the proposed method.",
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