Details
| Original language | English |
|---|---|
| Pages (from-to) | 553-567 |
| Number of pages | 15 |
| Journal | Biometrical journal |
| Volume | 42 |
| Issue number | 5 |
| Early online date | 5 Sept 2000 |
| Publication status | E-pub ahead of print - 5 Sept 2000 |
Abstract
Typical animal carcinogenicity studies involve the comparison of several dose groups to a negative control. The unconnected asymptotic Cochran-Armitage trend test with equally spaced dose scores is the most frequently used test in such set-ups. However, this test based on a weighted linear regression on proportions. It is well known that the Cochran-Armitage test lacks in power for other shapes than the assumed linear one. Therefore, dichotomous multiple contrast tests are introduced. These build the maximum over several single contrasts, where each of them is chosen appropriately to cover a specific dose-response shape. An extensive power study has been conducted to compare multiple contrast tests with the approaches used so far. Crucial results will be presented in this paper. Moreover, exact tests and continuity corrected versions are introduced and compared to the traditional uncorrected approaches regarding size and power behaviour. A trend test for any shape of the dose-response relationship for either crude tumour rates or mortality-adjusted rates based on the simple Poly-3 transformation is proposed for evaluation of carcinogenicity studies.
Keywords
- Animal carcinogenicity study, Cochran-armitage trend test, Multiple contrast tests, Poly-3 test
ASJC Scopus subject areas
- Mathematics(all)
- Statistics and Probability
- Decision Sciences(all)
- Statistics, Probability and Uncertainty
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In: Biometrical journal, Vol. 42, No. 5, 05.09.2000, p. 553-567.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Evaluation of animal carcinogenicity studies
T2 - Cochran-armitage trend test vs. multiple contrast tests
AU - Hothorn, Ludwig A.
AU - Bretz, Frank
PY - 2000/9/5
Y1 - 2000/9/5
N2 - Typical animal carcinogenicity studies involve the comparison of several dose groups to a negative control. The unconnected asymptotic Cochran-Armitage trend test with equally spaced dose scores is the most frequently used test in such set-ups. However, this test based on a weighted linear regression on proportions. It is well known that the Cochran-Armitage test lacks in power for other shapes than the assumed linear one. Therefore, dichotomous multiple contrast tests are introduced. These build the maximum over several single contrasts, where each of them is chosen appropriately to cover a specific dose-response shape. An extensive power study has been conducted to compare multiple contrast tests with the approaches used so far. Crucial results will be presented in this paper. Moreover, exact tests and continuity corrected versions are introduced and compared to the traditional uncorrected approaches regarding size and power behaviour. A trend test for any shape of the dose-response relationship for either crude tumour rates or mortality-adjusted rates based on the simple Poly-3 transformation is proposed for evaluation of carcinogenicity studies.
AB - Typical animal carcinogenicity studies involve the comparison of several dose groups to a negative control. The unconnected asymptotic Cochran-Armitage trend test with equally spaced dose scores is the most frequently used test in such set-ups. However, this test based on a weighted linear regression on proportions. It is well known that the Cochran-Armitage test lacks in power for other shapes than the assumed linear one. Therefore, dichotomous multiple contrast tests are introduced. These build the maximum over several single contrasts, where each of them is chosen appropriately to cover a specific dose-response shape. An extensive power study has been conducted to compare multiple contrast tests with the approaches used so far. Crucial results will be presented in this paper. Moreover, exact tests and continuity corrected versions are introduced and compared to the traditional uncorrected approaches regarding size and power behaviour. A trend test for any shape of the dose-response relationship for either crude tumour rates or mortality-adjusted rates based on the simple Poly-3 transformation is proposed for evaluation of carcinogenicity studies.
KW - Animal carcinogenicity study
KW - Cochran-armitage trend test
KW - Multiple contrast tests
KW - Poly-3 test
UR - http://www.scopus.com/inward/record.url?scp=0034557649&partnerID=8YFLogxK
U2 - 10.1002/1521-4036(200009)42:5<553::AID-BIMJ553>3.0.CO;2-R
DO - 10.1002/1521-4036(200009)42:5<553::AID-BIMJ553>3.0.CO;2-R
M3 - Review article
AN - SCOPUS:0034557649
VL - 42
SP - 553
EP - 567
JO - Biometrical journal
JF - Biometrical journal
SN - 0323-3847
IS - 5
ER -