Details
| Original language | English |
|---|---|
| Pages (from-to) | 5273-5275 |
| Number of pages | 3 |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue number | 36 |
| Publication status | Published - 28 Jun 2008 |
Abstract
In this work synthetic and semi-synthetic studies toward the antitumor active natural product tonantzitlolone B are described, starting with an advanced intermediate obtained from the total synthesis of tonantzitlolone and a natural sample of this compound, respectively. The unknown absolute configuration of the stereogenic center in the side chain was elucidated to be (R).
Keywords
- Diterpenes, Natural products, Semisynthesis, Structure elucidation, Total synthesis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Tetrahedron Letters, Vol. 49, No. 36, 28.06.2008, p. 5273-5275.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Determination of the absolute configuration of the diterpene tonantzitlolone B
AU - Busch, Torsten
AU - Schuster, Hannah
AU - Kirschning, Andreas
N1 - Funding information: The work was funded by a graduate scholarship for T.B. provided by the Stiftung Stipendien-Fonds des Verbandes der Chemischen Industrie. We thank AnalytiCon Discovery GmbH (Potsdam, Germany) for providing a sample of authentic Tonantzitlolone B.
PY - 2008/6/28
Y1 - 2008/6/28
N2 - In this work synthetic and semi-synthetic studies toward the antitumor active natural product tonantzitlolone B are described, starting with an advanced intermediate obtained from the total synthesis of tonantzitlolone and a natural sample of this compound, respectively. The unknown absolute configuration of the stereogenic center in the side chain was elucidated to be (R).
AB - In this work synthetic and semi-synthetic studies toward the antitumor active natural product tonantzitlolone B are described, starting with an advanced intermediate obtained from the total synthesis of tonantzitlolone and a natural sample of this compound, respectively. The unknown absolute configuration of the stereogenic center in the side chain was elucidated to be (R).
KW - Diterpenes
KW - Natural products
KW - Semisynthesis
KW - Structure elucidation
KW - Total synthesis
UR - http://www.scopus.com/inward/record.url?scp=47549104916&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2008.06.105
DO - 10.1016/j.tetlet.2008.06.105
M3 - Article
AN - SCOPUS:47549104916
VL - 49
SP - 5273
EP - 5275
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 36
ER -