Details
| Original language | English |
|---|---|
| Article number | 100436 |
| Journal | Acta Materialia |
| Volume | 8 |
| Early online date | 11 Aug 2019 |
| Publication status | Published - Dec 2019 |
Abstract
Porous magnesium implants have been investigated for some time for their orthopaedic applicability as resorbable bone substitutes. The objective of this study was to evaluate the in vivo degradation behaviour and osseointegration of open-pored scaffolds made of the two magnesium alloys, LAE442 (n = 40) and Mg-La2 (n = 40). Cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined interconnecting pore structure were produced by investment casting and coated with MgF2. Commercially available porous ß-tricalcium phosphate scaffolds (TCP, n = 40) of the same dimensions served as control. The scaffolds were inserted in the cancellous part of the greater trochanter of both femurs in rabbits and evaluated over a period of 36 weeks using regular clinical, radiological and in vivo µCT examinations. No clinical adverse reactions were observed in any of the scaffolds. The X-ray and µCT image evaluation of La2 showed fast and inhomogeneous degradation behaviour with increased gas formation and a rapid loss of scaffold structure and shape from week 12 on. In comparison, the LAE442 scaffolds showed a slow, homogeneous degradation with low but continuous gas production over the entire study period. Furthermore, LAE442 scaffolds showed comparatively better osseointegration with more trabecular contacts than La2 scaffolds and retained their original scaffold structure. Although the TCP control group demonstrated the best osseointegration, it showed overly-rapid degradation. Based on the results of this study, the LAE422 scaffolds have promising properties for further investigations in weight-bearing bone defects.
Keywords
- Biodegradable implants, Magnesium alloy, Micro-tomography, Osseointegration, Porous scaffolds
ASJC Scopus subject areas
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In: Acta Materialia, Vol. 8, 100436, 12.2019.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Comparison of degradation behaviour and osseointegration of the two magnesium scaffolds, LAE442 and La2, in vivo
AU - Kleer, N.
AU - Julmi, Stefan Michael
AU - Gartzke, Ann-Kathrin Sigrid Elisabeth
AU - Augustin, J.
AU - Feichtner, F.
AU - Waselau, Anja Christina
AU - Klose, Christian
AU - Maier, Hans Jürgen
AU - Wriggers, Peter
AU - Meyer-Lindenberg, Andrea
N1 - Funding information: This research was funded by the German Research Foundation (DFG) within the project “Interfacial effects and integration behaviour of magnesium-based sponges as bioresorbable bone substitute material” (Grant No. 271761343). The authors gratefully appreciate the financial support. Moreover, the authors thank Lisa Wurm and Beatrix Limmer for excellent technical support.
PY - 2019/12
Y1 - 2019/12
N2 - Porous magnesium implants have been investigated for some time for their orthopaedic applicability as resorbable bone substitutes. The objective of this study was to evaluate the in vivo degradation behaviour and osseointegration of open-pored scaffolds made of the two magnesium alloys, LAE442 (n = 40) and Mg-La2 (n = 40). Cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined interconnecting pore structure were produced by investment casting and coated with MgF2. Commercially available porous ß-tricalcium phosphate scaffolds (TCP, n = 40) of the same dimensions served as control. The scaffolds were inserted in the cancellous part of the greater trochanter of both femurs in rabbits and evaluated over a period of 36 weeks using regular clinical, radiological and in vivo µCT examinations. No clinical adverse reactions were observed in any of the scaffolds. The X-ray and µCT image evaluation of La2 showed fast and inhomogeneous degradation behaviour with increased gas formation and a rapid loss of scaffold structure and shape from week 12 on. In comparison, the LAE442 scaffolds showed a slow, homogeneous degradation with low but continuous gas production over the entire study period. Furthermore, LAE442 scaffolds showed comparatively better osseointegration with more trabecular contacts than La2 scaffolds and retained their original scaffold structure. Although the TCP control group demonstrated the best osseointegration, it showed overly-rapid degradation. Based on the results of this study, the LAE422 scaffolds have promising properties for further investigations in weight-bearing bone defects.
AB - Porous magnesium implants have been investigated for some time for their orthopaedic applicability as resorbable bone substitutes. The objective of this study was to evaluate the in vivo degradation behaviour and osseointegration of open-pored scaffolds made of the two magnesium alloys, LAE442 (n = 40) and Mg-La2 (n = 40). Cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined interconnecting pore structure were produced by investment casting and coated with MgF2. Commercially available porous ß-tricalcium phosphate scaffolds (TCP, n = 40) of the same dimensions served as control. The scaffolds were inserted in the cancellous part of the greater trochanter of both femurs in rabbits and evaluated over a period of 36 weeks using regular clinical, radiological and in vivo µCT examinations. No clinical adverse reactions were observed in any of the scaffolds. The X-ray and µCT image evaluation of La2 showed fast and inhomogeneous degradation behaviour with increased gas formation and a rapid loss of scaffold structure and shape from week 12 on. In comparison, the LAE442 scaffolds showed a slow, homogeneous degradation with low but continuous gas production over the entire study period. Furthermore, LAE442 scaffolds showed comparatively better osseointegration with more trabecular contacts than La2 scaffolds and retained their original scaffold structure. Although the TCP control group demonstrated the best osseointegration, it showed overly-rapid degradation. Based on the results of this study, the LAE422 scaffolds have promising properties for further investigations in weight-bearing bone defects.
KW - Biodegradable implants
KW - Magnesium alloy
KW - Micro-tomography
KW - Osseointegration
KW - Porous scaffolds
UR - http://www.scopus.com/inward/record.url?scp=85070768889&partnerID=8YFLogxK
U2 - 10.1016/j.mtla.2019.100436
DO - 10.1016/j.mtla.2019.100436
M3 - Article
AN - SCOPUS:85070768889
VL - 8
JO - Acta Materialia
JF - Acta Materialia
SN - 1359-6454
M1 - 100436
ER -