Details
| Original language | English |
|---|---|
| Title of host publication | Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease |
| Publisher | Elsevier |
| Chapter | 48 |
| Pages | 771-779 |
| Number of pages | 9 |
| ISBN (electronic) | 9780323913911 |
| ISBN (print) | 9780323916486 |
| Publication status | Published - 2022 |
| Externally published | Yes |
Abstract
It is widely accepted that increased pulse pressure and flow pulsatility are detrimental to peripheral end-organ structure and function. However, humans who have extremely low pulse pressure and flow pulsatility, such as patients implanted with a left ventricular assist device, also suffer severe end-organ complications. Consequently, studying these unique patients enables us to investigate the basic principles that govern regulation of the cardiovascular system across the full range of pulsatility. This chapter will highlight the unique arterial hemodynamics of heart failure patients living with nonpulsatile, continuous flow in their arterial system, after implantation with a left ventricular assist device. A description of the typical patient hemodynamics will form the basis of discussion and provide novel insights into how unique and extremely low pulsatile hemodynamics affect macro- and microcirculatory health. The study of low pulsatility hemodynamics can substantially enhance our understanding of arterial physiology and circulatory regulation.
Keywords
- Artery, Blood pressure, Continuous flow, Heart failure, Left ventricular assist device, Microcirculation, Pulsatility
ASJC Scopus subject areas
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Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease. Elsevier, 2022. p. 771-779.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Arterial stiffness, hemodynamics, and microvascular complications in conditions characterized by low arterial pulsatility
AU - McDonnell, Barry J.
AU - Cornwell , William K.
AU - Stöhr, Eric Jean
N1 - Publisher Copyright: © 2022 Elsevier Inc. All rights reserved.
PY - 2022
Y1 - 2022
N2 - It is widely accepted that increased pulse pressure and flow pulsatility are detrimental to peripheral end-organ structure and function. However, humans who have extremely low pulse pressure and flow pulsatility, such as patients implanted with a left ventricular assist device, also suffer severe end-organ complications. Consequently, studying these unique patients enables us to investigate the basic principles that govern regulation of the cardiovascular system across the full range of pulsatility. This chapter will highlight the unique arterial hemodynamics of heart failure patients living with nonpulsatile, continuous flow in their arterial system, after implantation with a left ventricular assist device. A description of the typical patient hemodynamics will form the basis of discussion and provide novel insights into how unique and extremely low pulsatile hemodynamics affect macro- and microcirculatory health. The study of low pulsatility hemodynamics can substantially enhance our understanding of arterial physiology and circulatory regulation.
AB - It is widely accepted that increased pulse pressure and flow pulsatility are detrimental to peripheral end-organ structure and function. However, humans who have extremely low pulse pressure and flow pulsatility, such as patients implanted with a left ventricular assist device, also suffer severe end-organ complications. Consequently, studying these unique patients enables us to investigate the basic principles that govern regulation of the cardiovascular system across the full range of pulsatility. This chapter will highlight the unique arterial hemodynamics of heart failure patients living with nonpulsatile, continuous flow in their arterial system, after implantation with a left ventricular assist device. A description of the typical patient hemodynamics will form the basis of discussion and provide novel insights into how unique and extremely low pulsatile hemodynamics affect macro- and microcirculatory health. The study of low pulsatility hemodynamics can substantially enhance our understanding of arterial physiology and circulatory regulation.
KW - Artery
KW - Blood pressure
KW - Continuous flow
KW - Heart failure
KW - Left ventricular assist device
KW - Microcirculation
KW - Pulsatility
UR - http://www.scopus.com/inward/record.url?scp=85162626939&partnerID=8YFLogxK
U2 - 10.1016/B978-0-323-91391-1.00048-0
DO - 10.1016/B978-0-323-91391-1.00048-0
M3 - Contribution to book/anthology
AN - SCOPUS:85162626939
SN - 9780323916486
SP - 771
EP - 779
BT - Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease
PB - Elsevier
ER -