Details
| Original language | English |
|---|---|
| Article number | 20160012 |
| Journal | BioNanoMaterials |
| Volume | 18 |
| Issue number | 1-2 |
| Publication status | Published - 31 Aug 2016 |
Abstract
Aptamers are promising alternative binders that can substitute antibodies in various applications. Due to the advantages of aptamers, namely their high affinity, specificity and stability, along with the benefits originating from the chemical synthesis of aptamers, they have attracted attention in various applications including their use on nanostructured material. This necessitates the immobilization of aptamers on a solid support. Since aptamer immobilization may interfere with its binding properties, the immobilization of aptamers has to be investigated and optimized. Within this review, we give general insights into the principles and factors controlling the binding affinity of immobilized aptamers. Specific features of aptamer immobilization on nanostructured surfaces and nanoparticles are highlighted and a brief overview of applications of aptamer-modified nanostructured materials is given.
Keywords
- applications, aptamer, immobilization, nanomaterial, nanoparticle
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Engineering(all)
- Biomedical Engineering
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In: BioNanoMaterials, Vol. 18, No. 1-2, 20160012, 31.08.2016.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Aptamer-modified nanomaterials:
T2 - Principles and applications
AU - Urmann, Katharina
AU - Modrejewski, Julia
AU - Scheper, Thomas
AU - Walter, Johanna G.
PY - 2016/8/31
Y1 - 2016/8/31
N2 - Aptamers are promising alternative binders that can substitute antibodies in various applications. Due to the advantages of aptamers, namely their high affinity, specificity and stability, along with the benefits originating from the chemical synthesis of aptamers, they have attracted attention in various applications including their use on nanostructured material. This necessitates the immobilization of aptamers on a solid support. Since aptamer immobilization may interfere with its binding properties, the immobilization of aptamers has to be investigated and optimized. Within this review, we give general insights into the principles and factors controlling the binding affinity of immobilized aptamers. Specific features of aptamer immobilization on nanostructured surfaces and nanoparticles are highlighted and a brief overview of applications of aptamer-modified nanostructured materials is given.
AB - Aptamers are promising alternative binders that can substitute antibodies in various applications. Due to the advantages of aptamers, namely their high affinity, specificity and stability, along with the benefits originating from the chemical synthesis of aptamers, they have attracted attention in various applications including their use on nanostructured material. This necessitates the immobilization of aptamers on a solid support. Since aptamer immobilization may interfere with its binding properties, the immobilization of aptamers has to be investigated and optimized. Within this review, we give general insights into the principles and factors controlling the binding affinity of immobilized aptamers. Specific features of aptamer immobilization on nanostructured surfaces and nanoparticles are highlighted and a brief overview of applications of aptamer-modified nanostructured materials is given.
KW - applications
KW - aptamer
KW - immobilization
KW - nanomaterial
KW - nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=85020454644&partnerID=8YFLogxK
U2 - 10.1515/bnm-2016-0012
DO - 10.1515/bnm-2016-0012
M3 - Review article
AN - SCOPUS:85020454644
VL - 18
JO - BioNanoMaterials
JF - BioNanoMaterials
SN - 2193-0651
IS - 1-2
M1 - 20160012
ER -