Details
| Original language | English |
|---|---|
| Pages (from-to) | 467-479 |
| Number of pages | 13 |
| Journal | Biometrical journal |
| Volume | 39 |
| Issue number | 4 |
| Early online date | 18 Jan 2007 |
| Publication status | E-pub ahead of print - 18 Jan 2007 |
Abstract
The power of single contrast tests strongly depends on the a priori unknown shape of the dose response relationship. Two approaches can be used to overcome this major disadvantage: the likelihood ratio test for order restriction or multiple contrast tests. Within the closure principle, the shape for the different hypotheses varies. Therefore multiple contrast tests are used as trend tests. Based on a simulation study the power advantage of this approach in comparison with single contrast tests is demonstrated.
Keywords
- Dose finding, minimum effective dose, Multiple contrast test, Trend test
ASJC Scopus subject areas
- Mathematics(all)
- Statistics and Probability
- Decision Sciences(all)
- Statistics, Probability and Uncertainty
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In: Biometrical journal, Vol. 39, No. 4, 18.01.2007, p. 467-479.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Analysis of randomized dose-finding-studies
T2 - Closure test modifications based on multiple contrast tests
AU - Hothorn, L. A.
AU - Neuhäuser, M.
AU - Koch, H. F.
PY - 2007/1/18
Y1 - 2007/1/18
N2 - The power of single contrast tests strongly depends on the a priori unknown shape of the dose response relationship. Two approaches can be used to overcome this major disadvantage: the likelihood ratio test for order restriction or multiple contrast tests. Within the closure principle, the shape for the different hypotheses varies. Therefore multiple contrast tests are used as trend tests. Based on a simulation study the power advantage of this approach in comparison with single contrast tests is demonstrated.
AB - The power of single contrast tests strongly depends on the a priori unknown shape of the dose response relationship. Two approaches can be used to overcome this major disadvantage: the likelihood ratio test for order restriction or multiple contrast tests. Within the closure principle, the shape for the different hypotheses varies. Therefore multiple contrast tests are used as trend tests. Based on a simulation study the power advantage of this approach in comparison with single contrast tests is demonstrated.
KW - Dose finding, minimum effective dose
KW - Multiple contrast test
KW - Trend test
UR - http://www.scopus.com/inward/record.url?scp=0039268959&partnerID=8YFLogxK
U2 - 10.1002/bimj.4710390408
DO - 10.1002/bimj.4710390408
M3 - Article
AN - SCOPUS:0039268959
VL - 39
SP - 467
EP - 479
JO - Biometrical journal
JF - Biometrical journal
SN - 0323-3847
IS - 4
ER -