Details
| Original language | English |
|---|---|
| Article number | 8214 |
| Number of pages | 9 |
| Journal | Scientific reports |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 8 Apr 2024 |
Abstract
The feasibility of low frequency pure tone generation in the inner ear by laser-induced nonlinear optoacoustic effect at the round window was demonstrated in three human cadaveric temporal bones (TB) using an integral pulse density modulation (IPDM). Nanosecond laser pulses with a wavelength in the near-infrared (NIR) region were delivered to the round window niche by an optical fiber with two spherical lenses glued to the end and a viscous gel at the site of the laser focus. Using IPDM, acoustic tones with frequencies between 20 Hz and 1 kHz were generated in the inner ear. The sound pressures in scala tympani and vestibuli were recorded and the intracochlear pressure difference (ICPD) was used to calculate the equivalent sound pressure level (eq. dB SPL) as an equivalent for perceived loudness. The results demonstrate that the optoacoustic effect produced sound pressure levels ranging from 140 eq. dB SPL at low frequencies ≤ 200 Hz to 90 eq. dB SPL at 1 kHz. Therefore, the produced sound pressure level is potentially sufficient for patients requiring acoustic low frequency stimulation. Hence, the presented method offers a potentially viable solution in the future to provide the acoustic stimulus component in combined electro-acoustic stimulation with a cochlear implant.
Keywords
- Active middle ear implant, Electro-acoustic stimulation, Optoacoustic
ASJC Scopus subject areas
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In: Scientific reports, Vol. 14, No. 1, 8214, 08.04.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Acoustic stimulation of the human round window by laser-induced nonlinear optoacoustics
AU - Lengert, Liza
AU - Tomanek, Michael
AU - Ghoncheh, Mohammad
AU - Lohmann, Hinnerk
AU - Prenzler, Nils
AU - Kalies, Stefan
AU - Johannsmeier, Sonja
AU - Ripken, Tammo
AU - Heisterkamp, Alexander
AU - Maier, Hannes
N1 - Funding Information: The project was sponsored by the cluster of excellence “Hearing4all” from the German research foundation (DFG), project EXC 2177.
PY - 2024/4/8
Y1 - 2024/4/8
N2 - The feasibility of low frequency pure tone generation in the inner ear by laser-induced nonlinear optoacoustic effect at the round window was demonstrated in three human cadaveric temporal bones (TB) using an integral pulse density modulation (IPDM). Nanosecond laser pulses with a wavelength in the near-infrared (NIR) region were delivered to the round window niche by an optical fiber with two spherical lenses glued to the end and a viscous gel at the site of the laser focus. Using IPDM, acoustic tones with frequencies between 20 Hz and 1 kHz were generated in the inner ear. The sound pressures in scala tympani and vestibuli were recorded and the intracochlear pressure difference (ICPD) was used to calculate the equivalent sound pressure level (eq. dB SPL) as an equivalent for perceived loudness. The results demonstrate that the optoacoustic effect produced sound pressure levels ranging from 140 eq. dB SPL at low frequencies ≤ 200 Hz to 90 eq. dB SPL at 1 kHz. Therefore, the produced sound pressure level is potentially sufficient for patients requiring acoustic low frequency stimulation. Hence, the presented method offers a potentially viable solution in the future to provide the acoustic stimulus component in combined electro-acoustic stimulation with a cochlear implant.
AB - The feasibility of low frequency pure tone generation in the inner ear by laser-induced nonlinear optoacoustic effect at the round window was demonstrated in three human cadaveric temporal bones (TB) using an integral pulse density modulation (IPDM). Nanosecond laser pulses with a wavelength in the near-infrared (NIR) region were delivered to the round window niche by an optical fiber with two spherical lenses glued to the end and a viscous gel at the site of the laser focus. Using IPDM, acoustic tones with frequencies between 20 Hz and 1 kHz were generated in the inner ear. The sound pressures in scala tympani and vestibuli were recorded and the intracochlear pressure difference (ICPD) was used to calculate the equivalent sound pressure level (eq. dB SPL) as an equivalent for perceived loudness. The results demonstrate that the optoacoustic effect produced sound pressure levels ranging from 140 eq. dB SPL at low frequencies ≤ 200 Hz to 90 eq. dB SPL at 1 kHz. Therefore, the produced sound pressure level is potentially sufficient for patients requiring acoustic low frequency stimulation. Hence, the presented method offers a potentially viable solution in the future to provide the acoustic stimulus component in combined electro-acoustic stimulation with a cochlear implant.
KW - Active middle ear implant
KW - Electro-acoustic stimulation
KW - Optoacoustic
UR - http://www.scopus.com/inward/record.url?scp=85189824384&partnerID=8YFLogxK
U2 - 10.1038/s41598-024-58129-0
DO - 10.1038/s41598-024-58129-0
M3 - Article
C2 - 38589426
AN - SCOPUS:85189824384
VL - 14
JO - Scientific reports
JF - Scientific reports
SN - 2045-2322
IS - 1
M1 - 8214
ER -