Details
| Original language | English |
|---|---|
| Publication status | E-pub ahead of print - 24 Jul 2020 |
Abstract
Keywords
- stat.AP
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
2020.
Research output: Working paper/Preprint › Preprint
}
TY - UNPB
T1 - A versatile trend test for the evaluation of tumor incidences in long-term carcinogenicity bioassays
AU - Hothorn, Ludwig A.
AU - Rahman, Atiar M.
AU - Schaarschmidt, Frank
PY - 2020/7/24
Y1 - 2020/7/24
N2 - For the evaluation of carcinogenicity bioassays a new trend test is proposed which is based on a maximum of arithmetic, ordinal, and logarithmic regression scores as well as the Williams-type contrasts for either crude proportions or more appropriate poly3-estimates for the tumor-by-time relationships. This test provides an almost appropriate power for most shapes of dose-response relationships (including for possible downturn effect at high(er) dose(s)), common signs of significance (p-value, confidence limits) and the information on the probable shape. Related software is easily available within the CRAN-packages tukeytrend, MCPAN, multcomp.
AB - For the evaluation of carcinogenicity bioassays a new trend test is proposed which is based on a maximum of arithmetic, ordinal, and logarithmic regression scores as well as the Williams-type contrasts for either crude proportions or more appropriate poly3-estimates for the tumor-by-time relationships. This test provides an almost appropriate power for most shapes of dose-response relationships (including for possible downturn effect at high(er) dose(s)), common signs of significance (p-value, confidence limits) and the information on the probable shape. Related software is easily available within the CRAN-packages tukeytrend, MCPAN, multcomp.
KW - stat.AP
M3 - Preprint
BT - A versatile trend test for the evaluation of tumor incidences in long-term carcinogenicity bioassays
ER -