Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1183-1199 |
| Seitenumfang | 17 |
| Fachzeitschrift | Synthesis |
| Ausgabenummer | 7 |
| Publikationsstatus | Veröffentlicht - 2 Mai 2005 |
Abstract
The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Organische Chemie
Ziele für nachhaltige Entwicklung
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in: Synthesis, Nr. 7, 02.05.2005, S. 1183-1199.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - Synthesis of the C1-C17 macrolactone of tedanolide
AU - Hassfeld, Jorma
AU - Eggert, Ulrike
AU - Kalesse, Markus
PY - 2005/5/2
Y1 - 2005/5/2
N2 - The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.
AB - The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.
KW - Aldol reactions
KW - Macrocycles
KW - Mitsunobu
KW - Tedanolide
KW - Total synthesis
UR - http://www.scopus.com/inward/record.url?scp=18744398182&partnerID=8YFLogxK
U2 - 10.1055/s-2005-865302
DO - 10.1055/s-2005-865302
M3 - Review article
AN - SCOPUS:18744398182
SP - 1183
EP - 1199
JO - Synthesis
JF - Synthesis
SN - 0039-7881
IS - 7
ER -