Surfactant Semiconductors as Trojan Horses in Cell-Membranes for On-Demand and Spatial Regulation of Oxidative Stress

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Marian Jaschke
  • Masina Plenge
  • Marius Kunkel
  • Tina Lehrich
  • Julia Schmidt
  • Kilian Stöckemann
  • Dag Heinemann
  • Stephan Siroky
  • Anaclet Ngezahayo
  • Sebastian Polarz
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Details

OriginalspracheEnglisch
Aufsatznummer2202290
Seitenumfang9
FachzeitschriftAdvanced healthcare materials
Jahrgang12
Ausgabenummer10
Frühes Online-Datum23 Dez. 2022
PublikationsstatusVeröffentlicht - 17 Apr. 2023

Abstract

Oxidative stress is a cause for numerous diseases and aging processes. Thus, researchers are keen to tune the level of intracellular stress and to learn from that. An unusual approach is presented here. The methodology involves multifunctional surfactants. Although their molecular design is nonbiological—a fullerenol head group attached covalently to pi-conjugated dyes—the surfactants possess superior biocompatibility. Using an intrinsic fluorescence signal as a probe, it is shown that the amphiphiles become incorporated into the Caco-2 cells. There, they are able to exhibit additional functions. The compound reduces cellular stress in dark reaction pathways. The antagonistic property is activated under irradiation, the photocatalytic production of reactive oxygen species (ROS), resulting in cell damage. The feature is activated even by near-infrared light (NIR-light) via a two-photon process. The properties as molecular semiconductors lead to a trojan horse situation and allows the programming of the spatial distribution of cytotoxicity.

ASJC Scopus Sachgebiete

Zitieren

Surfactant Semiconductors as Trojan Horses in Cell-Membranes for On-Demand and Spatial Regulation of Oxidative Stress. / Jaschke, Marian; Plenge, Masina; Kunkel, Marius et al.
in: Advanced healthcare materials, Jahrgang 12, Nr. 10, 2202290, 17.04.2023.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Jaschke, M, Plenge, M, Kunkel, M, Lehrich, T, Schmidt, J, Stöckemann, K, Heinemann, D, Siroky, S, Ngezahayo, A & Polarz, S 2023, 'Surfactant Semiconductors as Trojan Horses in Cell-Membranes for On-Demand and Spatial Regulation of Oxidative Stress', Advanced healthcare materials, Jg. 12, Nr. 10, 2202290. https://doi.org/10.1002/adhm.202202290
Jaschke, M., Plenge, M., Kunkel, M., Lehrich, T., Schmidt, J., Stöckemann, K., Heinemann, D., Siroky, S., Ngezahayo, A., & Polarz, S. (2023). Surfactant Semiconductors as Trojan Horses in Cell-Membranes for On-Demand and Spatial Regulation of Oxidative Stress. Advanced healthcare materials, 12(10), Artikel 2202290. https://doi.org/10.1002/adhm.202202290
Jaschke M, Plenge M, Kunkel M, Lehrich T, Schmidt J, Stöckemann K et al. Surfactant Semiconductors as Trojan Horses in Cell-Membranes for On-Demand and Spatial Regulation of Oxidative Stress. Advanced healthcare materials. 2023 Apr 17;12(10):2202290. Epub 2022 Dez 23. doi: 10.1002/adhm.202202290
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AU - Schmidt, Julia

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AU - Heinemann, Dag

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AU - Ngezahayo, Anaclet

AU - Polarz, Sebastian

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